Evidence map›Paper›PMID 39841588›Full record

ArticleJournal of the American Chemical Society2025

Hydrogen Tunneling and Conformational Motions in Nonadiabatic Proton-Coupled Electron Transfer between Interfacial Tyrosines in Ribonucleotide Reductase.

Jiayun Zhong, Qiwen Zhu, Alexander V Soudackov, Sharon Hammes-Schiffer

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Low-barrier hydrogen bond powers long-range radical transfer in the metal-free ribonucleotide reductase.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Allosteric gating of radical transport in ribonucleotide reductase.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Conformationally gated multisite proton-coupled electron transfer in the ribonucleotide reductaseProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiayun ZhongDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Qiwen ZhuDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-5845-8095
Alexander V SoudackovDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0001-9581-8494
Sharon Hammes-SchifferDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-3782-6995

Funding

Coupled Protons and Electrons in Biological SystemsR35GM139449 · NIGMS · YALE UNIVERSITY · PI HAMMES-SCHIFFER, SHARON · 2021 to 2025
$2.1M
NIGMS NIH HHS R35 GM139449
6 · The paper itself

Abstract

Ribonucleotide reductase (RNR) is essential for DNA synthesis and repair in all living organisms. The mechanism of

Indexed as

HydrogenProtonsRibonucleotide ReductasesTyrosineDensity Functional TheoryElectron TransportEscherichia coliHydrogen BondingMolecular Dynamics SimulationProtein ConformationHydrogenProtonsRibonucleotide ReductasesTyrosine

Identifiers

PMID39841588
PMCPMC11829447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.