Evidence map›Paper›PMID 39841576›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Next-Generation Photosensitizers: Cyanine-Carborane Salts for Superior Photodynamic Therapy of Metastatic Cancer.

Amir Roshanzadeh, Hyllana C D Medeiros, Christopher K Herrera, Carson Malhado, Anton W Tomich, Steven P Fisher, Sergio O Lovera, Matthew Bates, Vincent Lavallo, Richard R Lunt and 1 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Modern Cyanine Dye-Based Photosensitizers for Medical Applications.Angewandte Chemie (International ed. in English) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amir RoshanzadehDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, United States.
Hyllana C D MedeirosDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, United States.
Christopher K HerreraDepartment of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, United States.
Carson MalhadoDepartment of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, United States.
Anton W TomichDepartment of Chemistry, University of California, Riverside, CA 92521, United States.
Steven P FisherDepartment of Chemistry, University of California, Riverside, CA 92521, United States.
Sergio O LoveraDepartment of Chemistry, University of California, Riverside, CA 92521, United States.
Matthew BatesDepartment of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, United States.
Vincent LavalloDepartment of Chemistry, University of California, Riverside, CA 92521, United States.
Richard R LuntDepartment of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, United States.ORCID 0000-0003-4522-6065
Sophia Y LuntDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, United States.

Funding

Examining PHGDH-mediated activation of sialic acid metabolism to drive triple-negative breast cancer metastasisR01CA270136 · NCI · MICHIGAN STATE UNIVERSITY · PI Sophia Lunt · 2022 to 2026
$2.0M
Mechanistic role of obesity in benzo(a)pyrene-initiated cancerR01ES030695 · NIEHS · MICHIGAN STATE UNIVERSITY · PI BERNARD, JAMIE J · 2020 to 2023
$1.5M
National Cancer Institute of the National Institutes of Health R01CA270136National Institute of Environmental Health Sciences of the National Institutes of Health R01ES030695National Science Foundation CBET 1702591National Science Foundation under CAREER CBET 1845006NCI NIH HHS R01 CA270136NIEHS NIH HHS R01 ES030695UCOP CRCC C25CR8638
6 · The paper itself

Abstract

Photodynamic therapy (PDT) has emerged as a promising targeted treatment for cancer. However, current PDT is limited by low tissue penetration, insufficient phototoxicity (toxicity with light irradiation), and undesirable cytotoxicity (toxicity without light irradiation). Here, we report the discovery of cyanine-carborane salts as potent photosensitizers (PSs) that harness the near-infrared (NIR) absorbing [cyanine

Indexed as

Antineoplastic AgentsBoranesBreast NeoplasmsCarbocyaninesPhotochemotherapyPhotosensitizing AgentsAnimalsApoptosisCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorFemaleHumansMiceMolecular StructureReactive Oxygen SpeciesAntineoplastic AgentsBoranesCarbocyaninesPhotosensitizing AgentsReactive Oxygen SpeciesSaltsCarborane anionCyanineMetastatic breast cancerNear-infraredPhotodynamic therapy

Identifiers

PMID39841576
PMCPMC11848969

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.