Evidence map›Paper›PMID 39841546›Full record

ArticleThe journal of physical chemistry. B2025

Disassembly of Virus-Like Particles and the Stabilizing Role of the Nucleic Acid Cargo.

Amelia W Paine, Michael F Hagan, Vinothan N Manoharan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amelia W PaineHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.
Michael F HaganMartin Fisher School of Physics, Brandeis University, Waltham, Massachusetts 02453, United States.ORCID 0000-0002-9211-2434
Vinothan N ManoharanHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.ORCID 0000-0003-0370-6095

Funding

Computational modeling of viral capsid and bacterial microcompartment assemblyR01GM108021 · NIGMS · BRANDEIS UNIVERSITY · PI HAGAN, MICHAEL F · 2013 to 2021
$2.7M
NIGMS NIH HHS R01 GM108021
6 · The paper itself

Abstract

In many simple viruses and virus-like particles, the protein capsid self-assembles around a nucleic-acid genome. Although the assembly process has been studied in detail, relatively little is known about how the capsid disassembles, a potentially important step for infection (in viruses) or cargo delivery (in virus-like particles). We investigate capsid disassembly using a coarse-grained molecular dynamics model of a

Indexed as

CapsidNucleic AcidsCapsid ProteinsKineticsMolecular Dynamics SimulationOsmolar ConcentrationCapsid ProteinsNucleic Acids

Identifiers

PMID39841546
PMCPMC11822259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.