SynthesisClinical oral investigations2025
Autologous platelet concentrates as adjuncts to non-surgical periodontal therapy: a systematic review and meta-analysis.
Synthesis in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Enhancing wound healing in otorhinolaryngology with autologous platelet concentrates: a systematic review of clinical outcomes.The Journal of laryngology and otology · 2026Pooled it
- Non-surgical periodontal therapy with and without hyaluronic acid gel in type 2 diabetic stage-II periodontitis patients: a randomized clinical trial.BMC oral health · 2025Trial
- Injectable platelet-rich fibrin with vitamin C as an adjunct to non-surgical periodontal therapy in the treatment of stage-II periodontitis: a randomized controlled clinical trial.BMC oral health · 2025Trial
- Platelet-derived concentrates in the immunological management of periodontitis: from dysbiosis to personalized approaches.Odontology · 2026Review
- Platelet-Rich Concentrates in the Management of Lichen Planus-A Comprehensive Review.Journal of clinical medicine · 2025Review
- Low-Speed Platelet-Rich Fibrin Membrane in Conjunction With Demineralized Freeze-Dried Bone Allograft (DFDBA) Compared to Collagen Membrane With DFDBA in Noncontained Intraosseous Defects of Stage III Periodontitis: A Randomized Controlled Clinical Trial.International journal of dentistry · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the possible additional clinical benefit from autologous platelet concentrate (APC) treatment adjunct to non-surgical periodontal therapy (NSPT).
methodsElectronic (MEDLINE/Embase/Cochrane/MedNar/CORE) and hand searches were conducted. Following studies selection, evidence tables were formed, and meta-analyses were performed for the following outcomes: probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain, and bleeding on probing (BoP) reduction. The protocol for this systematic review was registered in PROSPERO (CRD42023514388).
resultsAfter de-duplication, the initial search yielded 194 citations, from which ten papers were eligible for quantitative synthesis. The APC group comprised 270 patients, while the control group included 230. The meta-analysis revealed that a single APC application resulted in a 0.6 mm greater PPD reduction (MD = -0.62; 95% CI: -1.03, -0.22) and 0.8 mm more CAL gain (MD = -0.77; 95% CI: -1.18, -0.37) at the 6-12 weeks follow-up. At six months, the APC group exhibited a 0.6 mm greater PPD reduction (MD = -0.61; 95% CI: -1.13, -0.09) and 1.1 mm more CAL gain (MD = -1.14; 95% CI: -1.94, -0.34) compared to the NSPT only group. In contrast, BoP indices did not reveal a statistically significant difference between the groups after 6-12 weeks (MD = -10.54; 95% CI: -25.21, 4.14). High heterogeneity and unclear to high risk of bias were detected.
conclusionOver six months, the adjunctive APC use appears to provide additional benefits in PPD reduction and CAL gain compared to NSPT alone. CLINICAL RELEVANCE: The adjunctive use of APCs seems to promote further improvements in clinical outcomes following NSPT.
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