Evidence map›Paper›PMID 39841046›Full record

ArticleInfection and immunity2025

MASP1 modulation as a novel therapeutic target in severe pediatric pertussis: insights from a multi-omics approach.

Lin Xu, Caiying Wang, Yuhuan Liu, Yanlan Zhang, Zhen Li, Lin Pang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lin XuDepartment of Pediatrics, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.ORCID 0009-0002-8609-0272
Caiying WangDepartment of Pediatrics, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.
Yuhuan LiuDepartment of Pediatrics, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.
Yanlan ZhangDepartment of Pediatrics, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.
Zhen LiBeijing Chaoyang District Center for Disease Control and Prevention, Beijing, China.
Lin PangDepartment of Pediatrics, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.ORCID 0009-0002-3532-0808

Funding

National Natural Science Foundation of China L202036
6 · The paper itself

Abstract

Pertussis, a severe infectious disease in children, has become increasingly prominent in recent years. This study aims to investigate the role of the MASP1 protein in severe pertussis in children through multi-omics analysis, providing a theoretical basis for the development of novel therapeutic strategies. The study retrieved macro-genome and 16S rRNA data of pediatric pertussis from public databases to analyze microbial diversity and specific flora abundance, conducting pathway functional enrichment analysis. Differential expression analysis of transcriptome data and Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis, combined with machine learning, identified the key gene MASP1. A

Indexed as

Mannose-Binding Protein-Associated Serine ProteasesWhooping CoughAnimalsBordetella pertussisCell LineChildDisease Models, AnimalEpithelial CellsFemaleGene Expression ProfilingHumansMaleMiceMultiomicsTranscriptomeMannose-Binding Protein-Associated Serine ProteasesMASP1 protein, humaninfection modelmachine learningMASP1 proteinmicrobial diversitypertussistranscriptome analysis

Identifiers

PMID39841046
PMCPMC11834402

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.