Evidence map›Paper›PMID 39840781›Full record

ArticleJournal of neurochemistry2025

Impacts of hnRNP A1 Splicing Inhibition on the Brain Remyelination Proteome.

Caroline Brandão-Teles, Victor Corasolla Carregari, Guilherme Reis-de-Oliveira, Bradley J Smith, Yane Chaves, Aline Valéria Sousa Santos, Erick Martins de Carvalho Pinheiro, Caio C Oliveira, Andre Schwambach Vieira, Fernanda Crunfli and 1 more

Abstract read
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In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Caroline Brandão-TelesLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.ORCID 0000-0002-0408-8965
Victor Corasolla CarregariLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Guilherme Reis-de-OliveiraLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Bradley J SmithLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Yane ChavesTranslational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Aline Valéria Sousa SantosLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Erick Martins de Carvalho PinheiroInstitute of Chemistry, University of Campinas, Campinas, São Paulo, Brazil.
Caio C OliveiraInstitute of Chemistry, University of Campinas, Campinas, São Paulo, Brazil.
Andre Schwambach VieiraLaboratory of Electrophysiology, Neurobiology and Behaviour, Department of Functional and Structural Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Fernanda CrunfliLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Daniel Martins-de-SouzaLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São Paulo 2017/25588-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/01410-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/01669-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/05155-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/22398-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/08885-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/11514-7
6 · The paper itself

Abstract

Oligodendrocytes, the myelinating cells in the central nervous system, are implicated in several neurological disorders marked by dysfunctional RNA-binding proteins (RBPs). The present study aimed at investigating the role of hnRNP A1 in the proteome of the corpus callosum, prefrontal cortex, and hippocampus of a murine cuprizone-induced demyelination model. Right after the cuprizone insult, we administered an hnRNP A1 splicing activity inhibitor and analyzed its impact on brain remyelination by nanoESI-LC-MS/MS label-free proteomic analysis to assess the biological processes affected in these brain regions. Significant alterations in essential myelination proteins highlighted the involvement of hnRNP A1 in maintaining myelin integrity. Pathways related to sphingolipid and endocannabinoid signaling were affected, as well as the synaptic vesicle cycle and GABAergic synapses. Although behavioral impairments were not observed, molecular changes suggest potential links to memory, synaptic function, and neurotransmission processes. These findings enhance our understanding of the multifaceted roles of hnRNP A1 in the central nervous system, providing valuable insights for future investigations and therapeutic interventions in neurodegenerative and demyelinating diseases.

Indexed as

BrainDemyelinating DiseasesHeterogeneous Nuclear Ribonucleoprotein A1ProteomeRemyelinationRNA SplicingAnimalsCuprizoneMaleMiceMice, Inbred C57BLProteomicsCuprizoneHeterogeneous Nuclear Ribonucleoprotein A1Hnrnpa1 protein, mouseProteome

Identifiers

PMID39840781
PMCPMC11752419

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.