Evidence map›Paper›PMID 39840545›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

ZnFe Layered Double Hydroxide Nanosheets Loaded with Cu Single-Atom Nanozymes with Multi-Enzyme-Like Catalytic Activities as an Effective Treatment for Bacterial Keratitis.

Keke Wang, Mao-Sen Yuan, Pengxiu Dai, Jing Li, Anju Tao, Xinke Zhang, Jinyi Wang, Qin Tu

Erratum issuedAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Advanced Therapeutic Approach Based on LDHs-Mimetic Oxidoreductase.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Recent Advances in Nanozymes Toward Diabetic Foot Ulcers.International journal of nanomedicine · 2026
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Keke WangCollege of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Mao-Sen YuanCollege of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Pengxiu DaiCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Jing LiCollege of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Anju TaoCollege of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Xinke ZhangCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Jinyi WangCollege of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Qin TuCollege of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.ORCID https://orcid.org/0000-0001-9045-5751

Funding

National Natural Science Foundation of China 22174109National Natural Science Foundation of China 22274132National Natural Science Foundation of China 22474112Natural Science Foundation of Shaanxi Province 2023-JC-YB-131
6 · The paper itself

Abstract

Bacterial keratitis (BK) is a type of corneal inflammation resulting from bacterial infection in the eye. Although nanozymes have been explored as promising materials in corneal wound healing, currently available nanozymes lack sufficient catalytic activity and the ability to penetrate bacterial biofilms, limiting their efficacy against the treatment of BK. To remedy this, ZnFe layered double hydroxide (ZnFe-LDH) nanosheets are loaded with Cu single-atom nanozymes (Cu-SAzymes) and aminated dextran (Dex-NH

Indexed as

CopperHydroxidesKeratitisNanostructuresAnimalsAnti-Bacterial AgentsBiofilmsCatalysisDisease Models, AnimalPseudomonas aeruginosaRabbitsWound HealingAnti-Bacterial AgentsCopperHydroxidesantibacterialbacterial keratitismulti‐enzyme‐like activitiesnanozymetarget‐oriented

Identifiers

PMID39840545
PMCPMC11905092

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.