Evidence map›Paper›PMID 39840460›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2025

Hypotensive Episodes on 24-Hour Ambulatory Blood Pressure and Cognitive Function: Insights From the SPRINT Study.

Wenxin Zhang, Susan Redline, Anand Viswanathan, Simon B Ascher, Darshana Hari, Stephen P Juraschek, Christophe Tzourio, Paul E Drawz, Lewis A Lipsitz, Murray A Mittleman and 1 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Recent developments and challenges in hypertensive dementia over the past year.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Wenxin ZhangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (W.Z., D.H., M.A.M., Y.M.).ORCID 0009-0004-3444-0757
Susan RedlineDivision of Sleep and Circadian Disorders (S.R.), Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-6585-1610
Anand ViswanathanDepartment of Neurology, Massachusetts General Hospital (A.V.), Harvard Medical School, Boston, MA.ORCID 0000-0001-5398-1816
Simon B AscherKidney Health Research Collaborative, Department of Medicine, San Francisco Veterans Affairs Health Care System and University of California San Francisco (S.B.A.).ORCID 0000-0003-3465-4208
Darshana HariDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (W.Z., D.H., M.A.M., Y.M.).
Stephen P JuraschekDepartment of Medicine, Beth Israel Deaconess Medical Center (S.P.J., L.A.L., M.A.M.), Harvard Medical School, Boston, MA.ORCID 0000-0003-4168-2696
Christophe TzourioUniversity of Bordeaux, Inserm, Bordeaux Population Health Research Center, France (C.T.).ORCID 0000-0002-6517-2984
Paul E DrawzDepartment of Medicine, Medical School, University of Minnesota, Minneapolis (P.E.D.).ORCID 0000-0001-7301-9253
Lewis A LipsitzDepartment of Medicine, Beth Israel Deaconess Medical Center (S.P.J., L.A.L., M.A.M.), Harvard Medical School, Boston, MA.ORCID 0000-0003-2344-1274
Murray A MittlemanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (W.Z., D.H., M.A.M., Y.M.).ORCID 0000-0001-9788-7274
Yuan MaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (W.Z., D.H., M.A.M., Y.M.).ORCID 0000-0002-0207-3620

Funding

Vascular Pathology in Early and Asymptomatic Cerebral Amyloid AngiopathyR01AG047975 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI VISWANATHAN, ANAND · 2014 to 2025
$7.5M
Validation of Small-Vessel Disease Neuroimaging Biomarkers in Cerebral Amyloid Angiopathy-Related Cognitive DeclineR01NS104130 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VISWANATHAN, ANAND · 2018 to 2022
$3.4M
Epidemiologic, imaging and pathological studies of the role of blood pressure variability in dementia etiologyR00AG071742 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI MA, YUAN · 2023 to 2025
$715k
Precision blood pressure control, cognition and adverse events in older adults: detecting heterogeneity in treatment effects in randomized trialsusing machine-learning approachesR03AG087481 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI MA, YUAN · 2024 to 2024
$303k
Epidemiologic, imaging and pathological studies of the role of blood pressure variability in dementia etiologyK99AG071742 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MA, YUAN · 2021 to 2022
$260k
NHLBI NIH HHS HHSN268200900040CNHLBI NIH HHS HHSN268200900046CNHLBI NIH HHS HHSN268200900047CNHLBI NIH HHS HHSN268200900048CNHLBI NIH HHS HHSN268200900049CNIA NIH HHS K99 AG071742NIA NIH HHS R00 AG071742NIA NIH HHS R01 AG047975NIA NIH HHS R03 AG087481NINDS NIH HHS R01 NS104130
6 · The paper itself

Abstract

backgroundHypotensive episodes detected by 24-hour ambulatory blood pressure (BP) monitoring capture daily cumulative hypotensive stress and could be clinically relevant to cognitive impairment, but this relationship remains unclear.

methodsWe included participants from the Systolic Blood Pressure Intervention Trial (receiving intensive or standard BP treatment) who had 24-hour ambulatory BP monitoring measured near the 27-month visit and subsequent biannual cognitive assessments. We evaluated the associations of hypotensive episodes (defined as systolic BP drops of ≥20 mm Hg between 2 consecutive measurements that reached <100 mm Hg) and hypotensive duration (cumulative time of systolic BP <100 mm Hg) with subsequent cognitive function using adjusted linear mixed models. We further assessed 24-hour average BP and variability.

resultsAmong 842 participants with treated hypertension (mean age, 71±9 years; 29% women), the presence (versus absence) of recurrent hypotensive episodes (11%) was associated with lower digit symbol coding scores (difference in

conclusionTwenty-four-hour hypotensive episodes were associated with worse cognitive function, especially in processing speed, and could be a novel marker for optimal BP control and dementia prevention.

Indexed as

Blood PressureBlood Pressure Monitoring, AmbulatoryCognitionCognitive DysfunctionHypertensionHypotensionAgedAntihypertensive AgentsFemaleHumansMaleMiddle AgedAntihypertensive Agentsblood pressurecognitiondementiahypertensionhypotension

Identifiers

PMID39840460
PMCPMC11922650

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.