ArticleCureus2024
Immunohistochemical Analysis of the p53 Protein in Colorectal Cancer: A Clinicopathological Study.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Interplay Between p53 and Wnt/β-Catenin Signaling in Colorectal Cancer: Associations with Mismatch Repair Status, Tumor Microenvironment, and Clinicopathological Outcomes.Current oncology (Toronto, Ont.) · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of p53 expression in colorectal cancer (CRC) was investigated in this immunohistochemical analysis of 110 CRC patients. The study aimed to explore the relationship between p53 expression and clinicopathological features, such as tumor grade, size, lymph node involvement, and molecular subtypes. The mean age of patients was 52.6 years, with a higher prevalence in men (60.7%). Tumor grades were balanced, with 12.9% in grade 1, 13.6% in grade 2, and 12.9% in grade 3. The majority of patients exhibited low to moderate p53 expression, with a mean of 32.58%. Higher p53 expression correlated with larger tumor size and more advanced stages. Notably, p53 overexpression was associated with lymph node involvement, suggesting its role in metastasis. The study also examined molecular markers, such as BRAF and KRAS mutations, and found their association with p53 expression. Microsatellite instability was present in 21.4% of cases, with implications for treatment decisions. The findings highlight p53 as a key marker in CRC progression, with potential prognostic value for personalized treatment strategies. Further studies, including survival analysis, are necessary to fully understand the clinical impact of p53 expression in CRC.
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Registered trials
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