ArticleCureus2024
Genetic Analysis of Intraductal Carcinoma of the Prostate Detected in High-Grade Prostatic Intraepithelial Neoplasia Cases.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background The accurate diagnosis of intraductal carcinoma of the prostate (IDC-P) is occasionally challenging due to the similarity in pathological morphology between IDC-P and high-grade prostatic intraepithelial neoplasia (HGPIN). In this report, we reviewed the pathology of cases previously diagnosed as HGPIN to search for IDC-P cases effectively. In addition, we examined whether those cases had genetic abnormalities. Methods We reviewed 98 patients with HGPIN who underwent prostatectomy at our hospital between 2011 and 2021. They were reviewed by three pathologists to search for IDC-P findings by adding immunostaining for basement membrane markers. Genetic testing of prostatectomy specimens was performed to identify the presence of gene mutations. Results The typical IDC-P was diagnosed in two of the 98 patients. The Gleason score of background prostate cancer (PCa) was 4+5 and 4+4. Genetic testing revealed several mutations in DNA repair-related genes, such as
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