ArticleCureus2024
Comparison of the Effectiveness of Different Antidepressants in Preventing Psychiatric Rehospitalization.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePatients with major depressive disorder (MDD) often face poor health outcomes. Additionally, patients with multiple hospitalizations tend to have worse predicted disease prognosis. Antidepressant medications remain a first-line treatment option for MDD, but data evaluating the effects of different antidepressants on psychiatric readmission rates is lacking. The objective of this study was to assess readmission rates based on antidepressant selection upon discharge from an inpatient psychiatric hospitalization.
methodsThis was a single-center, retrospective chart review evaluating psychiatric readmission rates of adults with MDD discharged on antidepressant therapy. The primary outcome was to compare 30-day psychiatric rehospitalization rates based on antidepressant treatment and secondary outcomes included six-month and one-year psychiatric rehospitalization based on antidepressant treatment. Odds ratios (OR), 95% confidence intervals (CI), and p-values were calculated to determine the odds of readmission in patients who were discharged on each antidepressant compared to patients who were discharged on an antidepressant other than that particular antidepressant.
resultsPatients who were discharged on sertraline were four times less likely to be readmitted within 30 days compared to the combined readmission rate of other antidepressants or multiple antidepressants (OR: 0.228, 95%CI: 0.053-0.978, p<0.05). Meanwhile, patients discharged on any combination of multiple antidepressants were more likely to be readmitted than patients discharged on only one antidepressant (OR: 4.517, 95%CI: 1.581-12.908, p<0.05). The antidepressant medications included in the study were bupropion, duloxetine, escitalopram, fluoxetine, mirtazapine, paroxetine, sertraline, trazodone, and venlafaxine.
conclusionCareful consideration should be taken when choosing antidepressant therapy for inpatient psychiatric patients as this may impact relapse of symptoms and readmission rates. Further research is needed to evaluate other factors that may influence psychiatric readmissions for MDD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.