ArticleWorld journal of gastroenterology2025
Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease.
Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- An Explainable Multimodal Model for Assessing Mucosal Healing in Small Bowel Crohn's Disease: A Multicenter Study with Prospective Validation.Journal of imaging informatics in medicine · 2026Article
- Imaging monitoring contributes to the "treat-to-target" strategy in the management of Crohn's disease.World journal of gastroenterology · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMucosal healing (MH) is the major therapeutic target for Crohn's disease (CD). As the most commonly involved intestinal segment, small bowel (SB) assessment is crucial for CD patients. Yet, it poses a significant challenge due to its limited accessibility through conventional endoscopic methods.
aimTo establish a noninvasive radiomic model based on computed tomography enterography (CTE) for MH assessment in SBCD patients.
methodsSeventy-three patients diagnosed with SBCD were included and divided into a training cohort (
resultsOf the 73 patients enrolled, 25 patients achieved MH. The radiomic-clinical nomogram had an area under the ROC curve of 0.961 (95% confidence interval: 0.886-1.000) in the training cohort and 0.958 (0.877-1.000) in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone, as demonstrated by DCA.
conclusionThese results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.
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