Evidence map›Paper›PMID 39839566›Full record

ArticleAmerican journal of cardiovascular disease2024

Prevalence of transthyretin cardiac amyloidosis in patients with aortic stenosis.

Rozana SadrAldin, Jamal Ahmed, Fahmi Alkaf, Mohammed K Ahmed, Zakaria Bin Mousa, Saad A AlQahtani, Hussein Farghaly, Zahra AlAsiri, Raneem Alodhaib, Shehana Bin Shigair and 5 more

Abstract read
In one paragraph

Article in American journal of cardiovascular disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. What Cardiologists Should Know About Amyloidosis.Journal of clinical medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rozana SadrAldinPrince Sultan Cardiac Centre, Heart Function Unit, Department of Adult Cardiology Riyadh, Saudi Arabia.
Jamal AhmedPrince Sultan Cardiac Centre, Heart Function Unit, Department of Adult Cardiology Riyadh, Saudi Arabia.
Fahmi AlkafPrince Sultan Cardiac Centre, Heart Function Unit, Department of Adult Cardiology Riyadh, Saudi Arabia.
Mohammed K AhmedPrince Sultan Cardiac Centre, Division of Echocardiography, Department of Adult Cardiology Riyadh, Saudi Arabia.
Zakaria Bin MousaPrince Sultan Cardiac Centre, Division of Echocardiography, Department of Adult Cardiology Riyadh, Saudi Arabia.
Saad A AlQahtaniPrince Sultan Military Medical City, Department of Nuclear Medicine Riyadh, Saudi Arabia.
Hussein FarghalyPrince Sultan Military Medical City, Department of Nuclear Medicine Riyadh, Saudi Arabia.
Zahra AlAsiriPrince Sultan Cardiac Centre, Department of Nursing Riyadh, Saudi Arabia.
Raneem AlodhaibPrince Sultan Cardiac Centre, Department of Nursing Riyadh, Saudi Arabia.
Shehana Bin ShigairPrince Sultan Cardiac Centre, Heart Function Unit, Department of Adult Cardiology Riyadh, Saudi Arabia.
Abdullah AlqarniPrince Sultan Military Medical City, Department of Nuclear Medicine Riyadh, Saudi Arabia.
Hussein AlAmriPrince Sultan Cardiac Centre, Division of Interventional Cardiology, Department of Adult Cardiology Riyadh, Saudi Arabia.
Abdulrahman AlmoghairiPrince Sultan Cardiac Centre, Division of Interventional Cardiology, Department of Adult Cardiology Riyadh, Saudi Arabia.
Saeed AlahmariPrince Sultan Cardiac Centre, Division of Echocardiography, Department of Adult Cardiology Riyadh, Saudi Arabia.
Abeer BakhshPrince Sultan Cardiac Centre, Heart Function Unit, Department of Adult Cardiology Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransthyretin cardiac amyloidosis (ATTRCA) is a prevalent disease, and it can be associated with heart failure (HF), left ventricle hypertrophy (LVH), atrial fibrillation (AF), and aortic stenosis (AS).

aimThe study aims to detect the prevalence of ATTRCA in the symptomatic AS population.

methodA single-center prospective study screening for ATTRCA in patients diagnosed with symptomatic severe AS undergoing aortic valve (AV) intervention.

resultsA total of 27 patients were enrolled, of which 15 (56%) were men. The mean age was 72.8 ± 10.5 years. HF symptoms were present in 11 (40.7%) patients at New York Heart Association (NYHA) class II, while 15 (55.6%) patients had NYHA class III symptoms. AF was present in 6 (22.2%) patients. The mean left ventricle ejection fraction (LVEF) was 49.4 ± 9.75%, and the mean stroke volume (SV) was 37.4 ± 8.7 ml/m

conclusionATTRCA is prevalent in AS patients; bone scintigraphy is recommended for screening AS patients for ATTRCA.

Indexed as

Aortic stenosisATTRCAcardiac amyloidosiscarpal tunnel syndromeheart failureHFpEFlow flow-low gradient aortic stenosisTAVR

Identifiers

PMID39839566
PMCPMC11744221

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.