Evidence map›Paper›PMID 39839442›Full record

ArticleBBA advances2025

Loss or inhibition of lysosomal acid lipase

Alena Akhmetshina, Laszlo Schooltink, Melina Amor, Katharina B Kuentzel, Silvia Rainer, Ananya Nandy, Hansjoerg Habisch, Tobias Madl, Elizabeth Rendina-Ruedy, Katharina Leithner and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BBA advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alena AkhmetshinaGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Laszlo SchooltinkGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Melina AmorGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Katharina B KuentzelGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Silvia RainerGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Ananya NandyDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Hansjoerg HabischOtto Loewi Research Center, Division of Medicinal Chemistry, Medical University of Graz, Graz, Austria.
Tobias MadlOtto Loewi Research Center, Division of Medicinal Chemistry, Medical University of Graz, Graz, Austria.
Elizabeth Rendina-RuedyDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Katharina LeithnerBioTechMed-Graz, Graz, Austria.
Nemanja VujićGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Dagmar KratkyGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle (SM) is essential for movement, stability, and overall body function, and it readily adapts to changes in energy demand. Myogenesis is energy-intensive and involves complex molecular and cellular events. We recently demonstrated that the absence of lysosomal acid lipase (LAL)

Indexed as

C2C12 cellsEnergy metabolismLALLAL deficiencyMyogenesisPrimary myoblastSkeletal muscle

Identifiers

PMID39839442
PMCPMC11745973

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.