Evidence map›Paper›PMID 39839346›Full record

ReviewAmerican journal of clinical and experimental immunology2024

Tertiary lymphoid structures in colorectal cancer - organization and immune cell interactions.

Maya Vladova Gulubova, Stefan P Valkanov, Maria Magdalena K Ignatova, Georgi A Minkov

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of clinical and experimental immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maya Vladova GulubovaClinics of Pathology, University Hospital "Prof. Dr. Stoyan Kirkovich" Stara Zagora, Bulgria.
Stefan P ValkanovClinics of Neurosurgery, University Hospital "Prof. Dr. Stoyan Kirkovich" Stara Zagora, Bulgria.
Maria Magdalena K IgnatovaComplex Oncology Centre Stara Zagora, Bulgria.
Georgi A MinkovDepartment of Surgery, Medical Faculty, Trakia University Stara Zagora, Bulgria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tertiary lymphoid structures (TLS), formerly recognized as Crohn's-like structures, serve as crucial biomarkers for evaluating the progression of colorectal cancer (CRC). Understanding their spatial distribution, cellular composition, and interactions within CRC is paramount for comprehending the immune response in the tumor microenvironment (TME). TLS are comprised of a T-cellular compartment and a B-cellular compartment, the latter encompassing follicular dendritic cells (FDCs), high endothelial venules (HEVs), and lymphatic vessels. While T helper cells predominate in cancer TLS, the specific functions of their subpopulations remain inadequately understood. Notably, T follicular helper (Tfh) cells play a central role in the activation of CD8

Indexed as

B cell activationcolorectal cancerdendritic cellsTertiary lymphoid structures (TLS)T helpers

Identifiers

PMID39839346
PMCPMC11744347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.