Evidence map›Paper›PMID 39839230›Full record

ArticleRSC advances2025

Minh Hien Nguyen, Nguyen Thien Han Le, Bui Quoc Huy Nguyen, Mai Thanh Thi Nguyen, Truong Nhat Van Do, Tho Huu Le, Vu Thanh Nguyen, Chia-Hung Yen

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Minh Hien NguyenUniversity of Health Sciences, Vietnam National University Ho Chi Minh City YA1 Administrative Building, Hai Thuong Lan Ong Street, Dong Hoa Ward Di An City Binh Duong Province 75308 Vietnam nmhien@uhsvnu.edu.vn (+84) 373 696 894.ORCID https://orcid.org/0000-0002-7483-9154
Nguyen Thien Han LeUniversity of Health Sciences, Vietnam National University Ho Chi Minh City YA1 Administrative Building, Hai Thuong Lan Ong Street, Dong Hoa Ward Di An City Binh Duong Province 75308 Vietnam nmhien@uhsvnu.edu.vn (+84) 373 696 894.
Bui Quoc Huy NguyenThe University of Danang - VN-UK Institute for Research and Executive Education 41 Le Duan Street, Hai Chau 1 Ward, Hai Chau District Danang City 50000 Vietnam.
Mai Thanh Thi NguyenVietnam National University Ho Chi Minh City Quarter 6, Linh Trung Ward, Thu Duc District Ho Chi Minh City 70000 Vietnam.
Truong Nhat Van DoVietnam National University Ho Chi Minh City Quarter 6, Linh Trung Ward, Thu Duc District Ho Chi Minh City 70000 Vietnam.
Tho Huu LeVietnam National University Ho Chi Minh City Quarter 6, Linh Trung Ward, Thu Duc District Ho Chi Minh City 70000 Vietnam.
Vu Thanh NguyenDivision of Aquacultural Biotechnology, Biotechnology Center of Ho Chi Minh City 2374, Highway 1, Quarter 2, Trung My Tay Ward, District 12 Ho Chi Minh City 70000 Vietnam.
Chia-Hung YenGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University No. 100, Shih-Chuan 1st Road, Sanmin District Kaohsiung City 80708 Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a leading global health concern, with over 20 million new cases and 9.7 million deaths reported in 2022. Chemotherapy remains a widely used treatment, but drug resistance, which affects up to 90% of treatment outcomes, significantly hampers its effectiveness. The transcription factor Nrf2, which is crucial for cellular defense against oxidative stress, plays a dual role in cancer treatment. Although Nrf2 activation can suppress early carcinogenesis, its overexpression in cancer cells contributes to drug resistance, resulting in poor patient outcomes. Thus, inhibiting Nrf2 has emerged as a promising strategy for overcoming cancer drug resistance. Natural compounds such as luteolin and brusatol have shown potential in inhibiting Nrf2, although with limitations. This study isolates and characterizes seven triterpenoids from the

Identifiers

PMID39839230
PMCPMC11749225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.