ArticleQuantitative imaging in medicine and surgery2025
High performance of the diffusion magnetic resonance imaging biomarker diffusion-derived 'vessel density' (DDVD) for separating placentas associated with pre-eclampsia from placentas in normal pregnancy.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- MDIFN: a deep learning-based multi-dimensional interaction fusion network for placental MRI segmentation.Quantitative imaging in medicine and surgery · 2026Article
- The role of number-of-excitations (NEX) for the usability of free-breathing acquired diffusion-derived 'vessel density' (DDVD) and slow diffusion coefficient (SDC) maps in separating liver cysts, hemangiomas, and solid masses with a focus on small lesions.Journal of gastrointestinal oncology · 2026Article
- Spatiotemporal characterization of placental hypoxia and microvascular dysfunction in a preeclampsia rat model using photoacoustic and contrast-enhanced ultrasound.Quantitative imaging in medicine and surgery · 2026Article
- Higher perfusion among breast malignant tumors than among breast benign lesions as demonstrated by diffusion-derived 'vessel density' (DDVD): a pilot study.Quantitative imaging in medicine and surgery · 2026Article
- Value of multimodal ultrasound assessment of placental dysfunction in gestational diabetes mellitus: a prospective study.Quantitative imaging in medicine and surgery · 2026Article
- Assessment of uteroplacental perfusion with 3D power Doppler for the early prediction of pre-eclampsia: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2025Article
- Lower diffusion-derived vessel density (DDVD) measure of liver focal nodular hyperplasia than those of hepatocellular carcinoma and liver metastasis allows potential differential diagnosis: quantitative and semi-quantitative analyses of two-center data.Journal of gastrointestinal oncology · 2025Article
- The relevance of placenta MRI diffusion-derived vessels density and morphological features in diagnosing placenta accreta spectrum.BMC medical imaging · 2025Article
- The rationale for proposing a magnetic resonance slow diffusion metric and its proof-of-concept testing showing spleen parenchyma and hepatocellular carcinoma have faster diffusion than liver parenchyma.Quantitative imaging in medicine and surgery · 2025Article
- The impacts of time of echo (TE) and time of repetition (TR) on diffusion-derived 'vessel density' (DDVD) measurement: examples of liver, spleen, and hepatocellular carcinoma.Quantitative imaging in medicine and surgery · 2025Article
- Magnetic resonance diffusion-derived vessel density (DDVD) as a valuable tissue perfusion biomarker for isocitrate dehydrogenase genotyping in diffuse gliomas.BMC medical imaging · 2025Article
- MRI signal simulation of liverQuantitative imaging in medicine and surgery · 2025Article
- Influences of the second motion probing gradientQuantitative imaging in medicine and surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diffusion-derived 'vessel density' (DDVD) is a surrogate of the area of micro-vessels per unit tissue. DDVD is calculated according to: DDVD (b0b50) = Sb0/ROIarea0 - Sb50/ROIarea50, where Sb0 and Sb50 refer to the tissue signal when Methods: Diffusion-weighted images with Results: The DDVD values of the control placentas [n=44, median: 67.53, 95% confidence interval (CI): 52.84-79.46] were significantly higher than those of the PE patients (n=25, median: 23.66, 95% CI: 17.22-45.57, P<0.0001), while there was no difference of the fetal brain DDVD values of the control cases (median: 29.5, 95% CI: 25.46-34.62) and those of PE patients (median: 33.6, 95% CI: 27.82-35.39, P=0.41). DDVDr results of the control cases (median: 2.00, 95% CI: 1.57-2.50) and PE patients (median: 0.81, 95% CI: 0.53-1.18, P<0.0001) were significantly different, with area under the receiver operating characteristic curve (AUROC) of 0.84 for separation. The AUROC was 0.92 for separation when only cases with gestation age (GA) ≤35 weeks were considered (control n=20, PE n=9). If only PE patients with fetal growth restriction (n=8) were compared with the controls (n=44), then AUROC was 0.96 for the separation. A trend was noted with GA and DDVDr negatively correlated in the control group (r=-0.26, P=0.085); however, such a trend was not observed for PE patients. A trend was observed with systolic blood pressure and DDVDr negatively correlated (r=-0.328, P=0.117). Conclusions: DDVDr may play an important role in patient PE prediction and follow-up.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.