ArticleQuantitative imaging in medicine and surgery2025
Quantitative assessment of early changes in myocardial extracellular volume during postoperative adjuvant chemotherapy in patients with breast cancer via dual-layer spectral detector computed tomography: a cohort study.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- CT-derived myocardial extracellular volume: current evidence, clinical utility, and the emerging role of photon-counting CT-a systematic review.European radiology experimental · 2026Pooled it
- Myocardial extracellular volume fraction in cardiac CT: comparison of deep learning reconstruction and iterative reconstruction.Journal of thoracic disease · 2026Article
- Feasibility of using synthetic myocardial extracellular volume fraction derived from blood CT attenuation for the differentiation of heart failure.The international journal of cardiovascular imaging · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The major of anticancer therapies induce a wide spectrum of cardiotoxic effects. Early identification of anticancer treatment-associated cardiotoxicity is critical to informing decisions on subsequent interventions. Myocardial extracellular volume (ECV) has been proposed as a useful parameter for quantifying the early cardiotoxicity of cancer-related treatment. This study used dual-layer spectral detector computed tomography (CT) technology to simultaneously assess cardiac function and myocardial ECV, characterizing the early changes in parameters during breast cancer therapy. Methods: A single-center cohort study was conducted that prospectively enrolled 40 women with breast cancer (mean age 47.5±10.8 years) who underwent postoperative adjuvant chemotherapy between January 12, 2022, and November 2, 2023, with available data from baseline to 3 months after chemotherapy of cardiac computed tomography (CCT), ultrasound cardiography (UCG), electrocardiography, and serum biomarkers. Midventricular and global ECVs of the left ventricle were measured based on an iodine map of the late enhancement phase of dual-layer spectral detector CT. Changes in cardiac function parameters, ECVs, and cardiac biomarkers from baseline to the 3-month follow-up were analyzed. Correlation coefficients between the changes in cardiac function parameters and ECVs were calculated. Results: Between baseline and 3 months, there was no significant change in left ventricular ejection fraction (LVEF) on UCG (67.1%±3.8% Conclusions: CCT-derived ECV was used to evaluate myocardial changes in the early stage of chemotherapy before LVEF significantly decreased. The increases in ECV were not correlated with LVEF. The changes in myocardial ECVs were moderately correlated with cardiac function parameters. ECV may be a useful biomarker for detecting cardiotoxicity in patients with breast cancer in the early stage of anticancer therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.