ArticleQuantitative imaging in medicine and surgery2025
Enhancement of the nontumor component in newly diagnosed glioblastoma as a more accurate predictor of local recurrence location: a multicenter study.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Temporal-spatial evolution of tumor habitat analysis: a bibliometric study on research hotspots and trends in medical imaging (2014-2025).Translational cancer research · 2026Article
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Authors and funding
8 authors.
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Abstract
Background: Although the spatial heterogeneity of glioblastoma (GBM) can be clearly mapped by the habitats generated by magnetic resonance imaging (MRI), the means to accurately predicting the spatial location of local recurrence (SLLR) remains a significant challenge. The aim of this study was to identify the different degrees enhancement of GBM, including the nontumor component and tumor component, and determine their relationship with SLLR. Methods: A retrospective analysis was performed from three tertiary medical centers, totaling 728 patients with 109 radiation-induced temporal lobe necrosis (TLN) of nasopharyngeal carcinoma (NPC) and 619 with GBM. The spatial location of nontumor component enhancement (SLNTE) and the spatial location of tumor component enhancement (SLTE) for the preoperative images of patients with GBM were identified using TLN as the nontumor component reference by clustering analysis, and then their relationship with the SLLR was analyzed. Decision tree models of 10-fold cross-validation based on SLNTE and SLTE built to predict the SLLR. The area under the curve (AUC) was used to evaluate the predictive efficacy of these models. Results: The SLNTE had a stronger spatial relationship with SLLR than did SLTE (χ Conclusions: Radiation-induced TLN of NPC is a highly effective reference indicator for detecting nontumor components. The tumor periphery adjacent to the nontumor component enhancement of GBM may be associated with a higher risk of local recurrence, which may provide a more accurate imaging basis for performing supertotal resection.
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