Evidence map›Paper›PMID 39838950›Full record

ArticleJournal of cell science2025

Meeting report - Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases.

Jens Waschke, Masayuki Amagai, Christoph Becker, Mario Delmar, Firat Duru, David R Garrod, Brenda Gerull, Kathleen J Green, Michael Hertl, Andrew P Kowalczyk and 7 more

Abstract readConference Proceedings
In one paragraph

Article in Journal of cell science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jens WaschkeChair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians-Universität LMU Munich, 80336 Munich, Germany.ORCID 0000-0003-1182-5422
Masayuki AmagaiDepartment of Dermatology, Keio University, 160-8582 Tokyo, Japan.
Christoph BeckerDepartment of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen-Nürnberg, Germany.
Mario DelmarThe Leon H Charney Division of Cardiology, NYU Grossman School of Medicine, New York, NY 10016, USA.
Firat DuruDepartment of Cardiac Arrhythmia and Electrophysiology, Clinic for Cardiology, University Heart Center Zurich and Center for Translational and Experimental Cardiology (CTEC), University of Zurich, 8952 Zurich, Switzerland.
David R GarrodFaculty of Biology, Medicine and Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
Brenda GerullComprehensive Heart Failure Center, Department of Internal Medicine I, University Hospital Würzburg, 97080 Würzburg, Germany.
Kathleen J GreenDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Michael HertlDepartment of Dermatology and Allergology, Philipps-University Marburg 35043, Marburg, Germany.
Andrew P KowalczykDepartment of Dermatology, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Carien M NiessenDepartment Cell Biology of the Skin, Cologne Excellence Cluster for Stress Responses in Ageing-associated diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, University of Cologne, Joseph Stelzmannstrasse 26, 50931 Cologne, Germany.
Asma NusratMucosal Biology and Inflammation Research Group, Department of Pathology, University of Michigan, 109 Zina Pitcher Place, 4057 Biomedical Science Research Building, Ann Arbor, MI 48109-2200, USA.
Camilla SchinnerInstitute of Anatomy and Experimental Morphology, Center for Experimental Medicine, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Nicolas SchlegelDepartment of General, Visceral, Transplant, Vascular and Paediatric Surgery University Hospital Würzburg, Wuerzburg 97080, Germany.
Sanjeevi SivasankarDepartment of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA.
Franziska VielmuthChair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians-Universität LMU Munich, 80336 Munich, Germany.
Volker SpindlerInstitute of Anatomy and Experimental Morphology, Center for Experimental Medicine, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-1302-5421

Funding

MOLECULAR GENETICS OF PEMPHIGUS FOLIACEUS ANTIGENR01AR041836 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1993 to 2026
$11.8M
DESMOPLAKIN FUNCTION IN EPIDERMISR01AR043380 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1996 to 2026
$7.0M
Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and MelanomaR01CA228196 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 2019 to 2026
$3.7M
NCI NIH HHS R01 CA228196NIAMS NIH HHS R01 AR041836NIAMS NIH HHS R01 AR043380
6 · The paper itself

Abstract

Desmosomes are adhesive cell contacts abundant in tissues exposed to mechanical strain, such as the stratified and simple epithelia of the epidermis and mucous membranes, as well as the myocardium. Besides their role in mechanical cell cohesion, desmosomes also modulate pathways important for tissue differentiation, wound healing and immune responses. Dysfunctional desmosomes, resulting from pathogenic variants in genes encoding desmosomal components, autoantibodies targeting desmosomal adhesion molecules or inflammation, cause the life-threatening diseases arrhythmogenic cardiomyopathy and pemphigus and contribute to the pathogenesis of inflammatory bowel diseases. The Alpine Desmosome Disease Meeting 2024 (ADDM 2024), held in Grainau, Germany in October 2024, connected international researchers from basic sciences with clinical experts from dermatology, cardiology, gastroenterology and surgery. The participants discussed recent advances, identified hot topics in desmosome biology and disease and provided new concepts for pathogenesis and treatment approaches.

Indexed as

DesmosomesAnimalsHumans

Identifiers

PMID39838950
PMCPMC11972074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.