ArticleChemphyschem : a European journal of chemical physics and physical chemistry2025
RF Heating Effects in CEST NMR with Hyperpolarized
Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Proposition of Hyper-Chemical Exchange Saturation Transfer Subtraction Spectroscopy to Detect Very Weak and Broad Signals Hidden Under Baseline and Widen Range of Materials Accessed by HyperpolarizedChemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- RF Heating Effects in CEST NMR with HyperpolarizedChemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Chemical exchange saturation transfer (CEST) improves the sensitivity of NMR but depending on the spin exchange kinetics, it can require substantial RF energy deposition to label magnetization. Potential side effects like RF-induced heating may occur and must be monitored. Here, we explore the parameter space considering not only undesired heating but also efficient CEST build-up (depolarization rate), spectral resolution (line width), and subsequent effects like changes in chemical shifts of CEST responses. We present a systematic study to compare conventional block pulse with shaped-pulse saturation and quantify how the effective average saturation power impacts these parameters. Pulse shape and nominal excitation bandwidth, however, turned out to have little impact on acquired z-spectra and temperature changes. This study illustrates how different exchange kinetics define different regimes of suitable RF power within the dynamic range of fully saturable magnetization from hyperpolarized
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