ArticleJournal of materials chemistry. B2025
Synergistic antibacterial drug elution from UHMWPE for load-bearing implants.
Article in Journal of materials chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Research Progress on Personalized Bone Implants Based on Additive Manufacturing.Micromachines · 2025Review
- Toughness measures in solid-state composites of ultra-high molecular weight polyethylene.Journal of the mechanical behavior of biomedical materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Total joint replacement is a successful procedure for restoring the patient's musculoskeletal mobility and quality of life, but it carries the risk of severe peri-prosthetic joint infections (PJI) and is accompanied by post-operative pain. Cocktails of multiple drugs are often used for prevention/treatment of PJI and for addressing pain. Local drug delivery systems are promising for improving the outcome of the treatment and decreasing the side effects of systemic drugs. To this end, the ultra-high molecular weight polyethylene (UHMWPE) bearing surface of the joint implant is here proposed as a platform for simultaneous release of multiple therapeutics. The combined use of non-antibiotic drugs and antibiotics, and their incorporation into UHMWPE allows to obtain novel antibacterial implant materials. The combined elution of analgesics and antibiotics from UHMWPE is found to be synergistically effective in eradicating
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Registered trials
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