ArticleAnalytical chemistry2025
Remote Deep-Ultraviolet Laser Ablation in Connection with Electrospray Ionization-Atmospheric Pressure Chemical Ionization (rDUVLAESCI): A Novel Dual Ionization Source for Molecular Mass Spectrometry.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel remote deep ultraviolet laser ablation inlet connected to a dual electrospray ionization-atmospheric pressure chemical ionization (rDUVLAESCI) source is presented. This system allows for the simultaneous and spatial acquisition of mass spectrometry (MS) data for organic molecules with diverse polarities and molecular weights. Deep 193 nm UV laser ablation was used to sample analytes from dried spots for molecular MS analysis precisely. Furthermore, molecular MS imaging (MSI) with a variable laser spot size down to 3 μm was demonstrated. The complementary ionization modes generated mass spectra with sufficient analyte signals, detecting a broad range of molecules from polar compounds like caffeine and PEG 600, to nonpolar analytes, such as anthracene and wax esters, all within a single analytical run. Detection limits were found in the tens of attomoles per ablated/desorbed pixel. The powerful capabilities of the fully automated rDUVLAESCI dual source were demonstrated by visualizing the spatial distribution of new psychoactive substances on latent fingerprints. MSI for both sebum components and psychoactive substances revealed a connection between the chemical evidence and biometrical information. The rDUVLAESCI-MSI enabled the unambiguous identification of individuals, even using partially overlapped latent fingerprints. This unique rDUVLAESCI approach, with its remote laser ablation unit, improved spatial resolution and analyte coverage, particularly for nonpolar compounds.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.