Evidence map›Paper›PMID 39838690›Full record

ArticleMacromolecular rapid communications2025

Lignin Molar Mass Estimation by Dispersion Analysis.

Tor I Simonsen, Demi T Djajadi, Andrea Ponzecchi, Claudia Crestini, Matteo Gigli, Massimo Sgarzi, Sune T Thomsen

Abstract read
In one paragraph

Article in Macromolecular rapid communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Lignin Molar Mass Estimation by Dispersion Analysis.Macromolecular rapid communications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tor I SimonsenDepartment of Geosciences and Natural Resource Management, University of Copenhagen, Frederiksberg C, Copenhagen, 1958, Denmark.ORCID https://orcid.org/0000-0003-2570-1463
Demi T DjajadiDepartment of Geosciences and Natural Resource Management, University of Copenhagen, Frederiksberg C, Copenhagen, 1958, Denmark.ORCID https://orcid.org/0000-0002-4131-3228
Andrea PonzecchiDepartment of Geosciences and Natural Resource Management, University of Copenhagen, Frederiksberg C, Copenhagen, 1958, Denmark.ORCID https://orcid.org/0009-0009-1654-6458
Claudia CrestiniDepartment of Molecular Sciences and Nanosystems, Ca' Foscari University, Venice, 30172, Italy.ORCID https://orcid.org/0000-0001-9903-2675
Matteo GigliDepartment of Molecular Sciences and Nanosystems, Ca' Foscari University, Venice, 30172, Italy.ORCID https://orcid.org/0000-0003-3899-0399
Massimo SgarziDepartment of Molecular Sciences and Nanosystems, Ca' Foscari University, Venice, 30172, Italy.ORCID https://orcid.org/0000-0001-6938-3909
Sune T ThomsenDepartment of Geosciences and Natural Resource Management, University of Copenhagen, Frederiksberg C, Copenhagen, 1958, Denmark.ORCID https://orcid.org/0000-0001-8908-9977

Funding

Danish Energy AgencyThe Energy Technology Development and Demonstration Program 64020-1101
6 · The paper itself

Abstract

Lignin's complex and heterogeneous molecular structure poses significant challenges for accurate molar mass determination, which is important for its utilization in industrial applications, such as biochemicals, nanoparticles, biobased binders, and biofuels. This study evaluates the potential of Taylor Dispersion Analysis (TDA) for measuring lignin size and compares it with size-exclusion chromatography (SEC) and diffusion-ordered spectroscopy (DOSY) NMR. Using dual Gaussian fitting, flow-induced dispersion analysis (FIDA), a TDA-based method, successfully determined the average hydrodynamic radii of multiple species in solvent-fractionated soda grass lignin samples, producing results consistent with DOSY. Molar mass calibration enabled comparisons between FIDA and SEC, revealing similar relative differences across lignin fractions. FIDA offers advantages such as rapid analysis and absence of stationary phase interactions, however its accuracy is limited by the variability of lignin fluorescence. Addressing these limitations will be critical for advancing FIDA as a method for lignin size estimation.

Indexed as

LigninChromatography, GelMagnetic Resonance SpectroscopyMolecular WeightLignindiffusion‐ordered spectroscopy (DOSY)flow‐induced dispersion analysis (FIDA)hydrodynamic radiussize‐exclusion chromatography (SEC)Taylor dispersion analysis (TDA)

Identifiers

PMID39838690
PMCPMC11925321

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.