ArticleCurrent pharmaceutical biotechnology2026
Nutritional Evaluation and Free Radical Scavenging Activity of Nano-formulated Selenium-Moringa Peregrine Seed Extract as a Promising Suppressor of TGF-β1/P38/NF-kβ Signaling Pathway in HgCl
Article in Current pharmaceutical biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMoringa peregrina, renowned for its extensive health benefits, continues to reveal its therapeutic potential through ongoing research. The synthesis of Moringa peregrina extract-selenium nanoparticles (MPE-SeNPs) has emerged as a promising approach in developing versatile therapeutic agents.
objectiveTo evaluate the protective effects of MPE-SeNPs against oxidative damage and inflammation caused by HgCl
methodsThe study involved extracting and characterizing the dried powdered seeds of Moringa peregrina to determine their nutritional and bioactive contents. MPE-SeNPs were synthesized using plant extracts and characterized through TEM, UV-Vis, and FT-IR techniques to assess their chelating and superoxide radical scavenging activities. The LD50 of MPE-SeNPs was determined, and doses of 1/50 and 1/20 of the LD50 were administered to HgCl
resultsThe raw Moringa peregrine seeds contain approximately 27.81% fat, 32.10% protein, 13.11% fiber, 4.11% ash and 22.93% carbohydrate content. The phenolic and flavonoid content in debittered seeds is approximately 76.42 mg of GAE/g DE), and 15.55 mg of QE/g DE, respectively. However, MPE and MPESeNPs exhibited chelating activity with 54 and 80.64% after 60 min. Additionally, at a concentration of 120 μg/mL, the superoxide radical scavenging activity was 71% for MPE and 93% for MPE-SeNPs after 5 minutes of incubation. The IC50 values recorded for MPE and MPE-SeNPs were 80.38 and 48.01 μg/mL, respectively. MPE-SeNPs had an average size of approximately 130.63 nm. UV-Vis spectrum peaks and FTIR identified functional groups associated with phenolics and flavonoids. LD50 of MPE-SeNPs was estimated to be 773 mg/kg body weight. Oral administration of MPE and MPE-SeNPs led to improvements in plasma lipid profile as well as lung antioxidant status. Moreover, downregulation of lung TGF-β1, P38, and NF-kβ gene expression in HgCl
conclusionThe study reveals that Moringa peregrina extract combined with selenium nanoparticles (MPESeNPs) offers significant protection against oxidative damage induced by HgCl
Indexed as
Identifiers
39838660What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.