ArticlePhotochemistry and photobiology
Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Anatomy-resolved digital twin framework for personalized light dosimetry in lung therapies.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- 3D Reactive Oxygen Species Dosimetry in Pleural Photodynamic Therapy: Integration of Macroscopic Kinetic Modeling and Deformable Registration.Antioxidants (Basel, Switzerland) · 2026Article
- Monte Carlo analysis of light fluence rate distribution in pleural photodynamic therapy: a study of geometric and optical property effects on treatment delivery.Journal of biomedical optics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Photodynamic therapy (PDT) has shown promise as an adjuvant treatment for malignant pleural mesothelioma when combined with surgical resection. Accurate light dosimetry is critical for treatment efficacy. This study presents an improved method for analyzing light fluence distribution in pleural PDT using a standardized anatomical coordinate system and advanced computational modeling. We utilized an infrared navigation system with an improved treatment delivery wand to track light delivery in real-time. The human chest cavity geometry was reconstructed and the pleura was mapped to a standardized coordinate system, allowing for direct comparisons across patients. Light fluence was calculated using both primary and scattered components, with a novel dual correction method applied to match measured values at detector locations. The standardized approach allowed for statistical analysis of light fluence distribution across anatomical regions in a cohort of 11 patients. Results showed acceptable light fluence uniformity with a standard deviation of 6.6% from the prescribed dose across patients. This comprehensive analysis provides insights for optimizing treatment protocols and lays the groundwork for future studies on singlet oxygen generation and its correlation with treatment outcomes in pleural PDT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.