Evidence map›Paper›PMID 39838644›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2025

Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease.

Gang Liu, Alan C Hsu, Silke Geirnaert, Christine Cong, Prema M Nair, Sj Shen, Jacqueline E Marshall, Tatt Jhong Haw, Michael Fricker, Ashleigh M Philp and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. LAMC2 Drives Airway Remodeling in COPD via EMT Regulation Through the AKT Pathway.International journal of chronic obstructive pulmonary disease · 2026
    Article
  6. The bronchoalveolar proteome changes in obesity.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Gang LiuSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia. Electronic address: gang.liu@uts.edu.au.
Alan C HsuImmune Health, Hunter Medical Research Institute and The University of Newcastle, Newcastle, NSW, Australia.
Silke GeirnaertLaboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Christine CongPulmonary and Critical Care Division, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Prema M NairImmune Health, Hunter Medical Research Institute and The University of Newcastle, Newcastle, NSW, Australia.
Sj ShenCentre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW, Australia.
Jacqueline E MarshallCentre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW, Australia.
Tatt Jhong HawImmune Health, Hunter Medical Research Institute and The University of Newcastle, Newcastle, NSW, Australia.
Michael FrickerImmune Health, Hunter Medical Research Institute and The University of Newcastle, Newcastle, NSW, Australia.
Ashleigh M PhilpCentre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW, Australia; St Vincent's Medical School, University of New South Wale Medicine, University of New South Wale, Sydney, NSW, Australia.
Nicole G HansbroCentre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW, Australia.
Stelios PavlidisThe Airway Disease Section, Data Science Institute, National Heart & Lung Institute, Imperial College London, London, UK.
Yike GuoData Science Institute, National Heart & Lung Institute, Imperial College London, London, UK.
Janette K BurgessUniversity of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen Research Institute of Asthma and COPD, Groningen, the Netherlands.
Leandro CastellanoSchool of Life Sciences, University of Sussex, Falmer, Brighton, UK.
Antonio IeniDepartment of Pathology, University of Messina, Messina, Italy.
Gaetano CaramoriPulmonology, Department of Medicine and Surgery, University of Parma, Parma PR, Italy.
Brain G G OliverSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
K Fan ChungThe Airway Disease Section, Data Science Institute, National Heart & Lung Institute, Imperial College London, London, UK.
Ian M AdcockData Science Institute, National Heart & Lung Institute, Imperial College London, London, UK.
Darryl A KnightImmune Health, Hunter Medical Research Institute and The University of Newcastle, Newcastle, NSW, Australia; Research and Academic Affairs, Providence Health Care Research Institute, Vancouver, BC, Canada; Departemnt of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Faculty of Medicine, Vancouver, BC, Canada.
Francesca PolverinoPulmonary and Critical Care Division, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Ken BrackeLaboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Peter A WarkImmune Health, Hunter Medical Research Institute and The University of Newcastle, Newcastle, NSW, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia.
Philip M HansbroImmune Health, Hunter Medical Research Institute and The University of Newcastle, Newcastle, NSW, Australia; Centre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW, Australia. Electronic address: philip.hansbro@uts.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitronectin (VTN) is an important extracellular matrix protein in tissue remodeling, but its role in chronic obstructive pulmonary disease (COPD) is unknown. We show that VTN regulates tissue remodeling through urokinase plasminogen activator (uPA) signaling pathway in COPD. In human COPD airways and bronchoepithelial cells and the airways of mice with cigarette smoke (CS)-induced experimental COPD, VTN protein was not changed, but downstream uPA signaling was altered (increased plasminogen activator inhibitor-1) that induced collagen and airway remodeling. In the parenchyma, VTN levels were decreased, uPA signaling pathway differentially altered and collagen reduced in lung fibroblasts from human and lung parenchyma in experimental COPD. Vtn inhibition with siRNA in mouse fibroblasts altered uPA signaling increased matrix metalloproteinase-12, and reduced collagen, whereas over-expression restored collagen production after CS extract challenge. Vtn

Indexed as

Airway RemodelingEmphysemaLungPulmonary Disease, Chronic ObstructivePulmonary EmphysemaVitronectinAnimalsCollagenDisease Models, AnimalFibroblastsHumansMaleMatrix Metalloproteinase 12MiceMice, KnockoutSignal TransductionCollagenMatrix Metalloproteinase 12Urokinase-Type Plasminogen ActivatorVitronectinCOPDemphysemaremodelinguPA pathwayvitronectin

Identifiers

PMID39838644
PMCPMC11897773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.