Evidence map›Paper›PMID 39838470›Full record

ArticleMolecular brain2025

Distribution and functional significance of KLF15 in mouse cerebellum.

Dan Li, Shuijing Cao, Yanrong Chen, Yueyan Liu, Kugeng Huo, Zhuangqi Shi, Shuxin Han, Liecheng Wang

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In one paragraph

Article in Molecular brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Dan LiDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, 230032, China.
Shuijing CaoDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, 230032, China.
Yanrong ChenDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, 230032, China.
Yueyan LiuDepartment of Basic Medicine, Department of Clinical Medicine, West Anhui Health Vocational College, Liuan, Anhui, 237000, China.
Kugeng HuoCyagen Biosciences (Guangzhou) Inc., Guangzhou, Guangdong, 510663, China.
Zhuangqi ShiXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang, 830017, China.
Shuxin HanXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang, 830017, China. hansx@xju.edu.cn.
Liecheng WangDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, 230032, China. wangliecheng2022@163.com.

Funding

Anhui. Provincial Natural Science Foundation 2308085MC83National Natural Science Foundation of China 31800997, 81971236, 81571293Natural Science Foundation of Universities of Anhui Province 2022AH050783
6 · The paper itself

Abstract

Kruppel-like factor 15 (KLF15), a member of the KLF family, is closely involved in many biological processes. However, the mechanism by which KLF15 regulates neural development is still unclear. Considering the complexity and importance of neural network development, in this study, we investigated the potent regulatory role of KLF15 in neural network development. KLF15 was detected highly expressed in the cerebellum and enriched in Purkinje cells, with a significant increase in KLF15 expression between 15 and 20 days of neural development. Knockdown of KLF15 led to loss of Purkinje cells and impaired motility in mice. Therefore, our study aims to elucidate the relationship between KLF15 and Purkinje cells in mice, may provide a new research idea for the developmental mechanism of the mouse cerebellum.

Indexed as

CerebellumKruppel-Like Transcription FactorsTranscription FactorsAnimalsCell MovementGene Expression Regulation, DevelopmentalGene Knockdown TechniquesMiceMice, Inbred C57BLPurkinje CellsTissue DistributionKlf15 protein, mouseKruppel-Like Transcription FactorsTranscription FactorsAtaxiaCerebellumGait analysisKLF15Neural developmentNeurotransmittersPurkinje cellsTranscription factor

Identifiers

PMID39838470
PMCPMC11749119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.