Evidence map›Paper›PMID 39838377›Full record

ArticleJournal of translational medicine2025

Oxidative stress and retinopathy: evidence from epidemiological studies.

Xiangliang Liu, Yu Chang, Yuguang Li, Yingrui Liu, Wei Song, Jin Lu, Naifei Chen, Jiuwei Cui

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Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiangliang Liu *Cancer Center, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, China.
Yu Chang *Cancer Center, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, China.
Yuguang Li *Cancer Center, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, China.
Yingrui LiuOphthalmology, Shenzhen People's Hospital, Shenzhen, China.
Wei SongCancer Center, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, China.
Jin LuCancer Center, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, China.
Naifei ChenCancer Center, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, China. chennaifei@jlu.edu.cn.
Jiuwei CuiCancer Center, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, China. cuijw@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have suggested oxidative stress may play a key role in the pathogenesis of retinopathy, while evidence from observational studies directly linking oxidative biomarkers to clinically relevant outcomes has been limited. This study aims to investigate the association between oxidative balance score (OBS) and prevalence of retinopathy in a nationally representative sample of U.S. adults, including both those with and without diabetes.

methodsData were obtained from the NHANES 2005-2008, including 3,287 participants. OBS was calculated from 16 dietary and 4 lifestyle components and categorized into tertiles. Weighted logistic regression was used to assess the association between OBS and retinopathy in the overall, diabetic, and non-diabetic populations, and Cox proportional hazards models evaluated the link between OBS and all-cause mortality in those with retinopathy. Restricted cubic spline (RCS) analysis explored the dose-response relationship between OBS and retinopathy. Subgroup analyses and interaction tests were conducted based on age, sex, race, BMI, education level, and diabetes status.

resultsParticipants in the highest OBS tertile had a 28% lower risk of retinopathy compared to those in the lowest tertile (OR 0.72, 95% CI 0.54-0.95, P = 0.023). RCS analysis showed a significant overall association between higher OBS and reduced retinopathy risk, without a nonlinear pattern. In participants with retinopathy, higher OBS was linked to a 60% reduction in all-cause mortality (HR 0.40, 95% CI 0.24-0.66, P < 0.001). Subgroup analysis revealed stronger inverse associations between OBS and retinopathy in younger individuals and those with higher education, with a significant interaction between OBS and age (P for interaction < 0.05).

conclusionOur study provides evidence that higher cumulative antioxidant exposure assessed by OBS is associated with a reduced risk and severity of retinopathy and lower all-cause mortality in U.S. adults with retinopathy, highlighting the importance of maintaining a favorable oxidative balance in retinal health.

Indexed as

Epidemiologic StudiesOxidative StressRetinal DiseasesAdultDiabetic RetinopathyFemaleHumansMaleMiddle AgedNutrition SurveysProportional Hazards ModelsRisk FactorsUnited StatesDiabetesMortalityNHANESOxidative balance scoreRetinopathy

Identifiers

PMID39838377
PMCPMC11748554

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.