ArticleBMC cancer2025
Gross recurrent laryngeal nerve invasion by extranodal extension in thyroid carcinoma.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Diagnostic performance of ultrasonography in predicting extrathyroidal extension in papillary thyroid carcinoma.BMC medical imaging · 2026Article
- Comparison of ultrasound-guided percutaneous radiofrequency ablation and reoperation for nerve-adjacent cervical lymph node recurrence of papillary thyroid carcinoma: a propensity score-matched study.Frontiers in endocrinology · 2026Article
- Machine-learning prediction of 3- and 5-year mortality in lymph-node-positive medullary thyroid carcinoma: a study based on the SEER database and external validation in a Chinese cohort.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundLymphatic metastasis commonly occurs in patients with papillary thyroid carcinoma and medullary thyroid carcinoma. The clinical and imaging characteristics of recurrent laryngeal nerve (RLN) invasion by extranodal extension (ENE) of metastatic lymph nodes remain understudied. This study aimed to evaluate these characteristics in patients with thyroid carcinoma.
methodsA retrospective cohort study was conducted on 77 patients treated between January 2012 and March 2024 with thyroid carcinoma demonstrating gross RLN invasion during surgery. Fifteen patients with gross RLN invasion by ENE of the metastatic lymph nodes were included. The primary endpoint was the percentage of preserved nerves. The secondary endpoints included vocal cord function and recurrence-free survival.
resultsFourteen patients had papillary thyroid carcinoma (PTC), and one had medullary thyroid carcinoma (MTC). There was no case of distant metastasis in the series. In the PTC group, two patients presented with hoarseness. There were two (14.3%) cases of T1a, six (42.9%) cases of T1b, and nine (64.3%) cases with concomitant lateral lymph node metastasis. The stage of the MTC case was T3bN1a. Among all the cases included, ten (67.7%) and five (33.3%) right and left RLNs, respectively, were invaded by ENE of the central compartment lymph nodes. Ultrasonography showed lymph nodes wrapping beyond half of the circumference of the RLNs and indistinct boundaries between the nodes and RLNs. Seven patients (46.7%) had the tumor shaved off from the epineurium, and three (20.0%) had the integrity of the RLNs preserved with gross residual tumor. Permanent vocal cord paralysis occurred in two (13.3%) cases receiving neurectomy, of which one was of the PTC group, and the other one belonged to the MTC group. At the end of the follow-up period, two patients in the PTC group experienced locoregional recurrence.
conclusionsMost patients with RLN invasion by ENE were asymptomatic. Sonography is feasible for assessing the location of metastatic lymph nodes in relation to the RLN in this preliminary study. Careful central compartment evaluation for patients with lymphatic metastases from thyroid carcinoma is conducive to nerve preservation and radical resection of lesions, especially for patients with MTC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.