Evidence map›Paper›PMID 39838246›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2025

A Japanese family of hereditary diffuse gastric cancer with a germline pathogenic variant of CTNN1A detected via comprehensive genome profiling.

Takeshi Kawakami, Hiroyuki Matsubayashi, Yoshimi Kiyozumi, Rina Harada, Eiko Ishihara, Masao Yoshida, Hiroyuki Ono, Etsuro Bando, Masakuni Serizawa, Takashi Sugino

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In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takeshi Kawakami *Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Hiroyuki Matsubayashi *Division of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan. h.matsubayashi@scchr.jp.ORCID 0000-0002-7050-2351
Yoshimi KiyozumiDivision of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan.
Rina HaradaDivision of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan.
Eiko IshiharaDivision of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan.
Masao YoshidaDivision of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
Hiroyuki OnoDivision of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
Etsuro BandoDivision of Gastric Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Masakuni SerizawaShizuoka Cancer Center Research Institute, Shizuoka, Japan.
Takashi SuginoDivision of Pathology, Shizuoka Cancer Center, Shizuoka, Japan.

Funding

KAKENHI 19K19372
6 · The paper itself

Abstract

CTNNA1 codes α-1 catenin, a molecule that functions in intercellular adhesion in combination with E-cadherin (coded by CDH1). A germline pathogenic variant (GPV) of CTNNA1 increases the risk of hereditary diffuse gastric cancer (HDGC); however, this GPV has not been reported in Japan. A 35-year-old Japanese man with an advanced gastric cancer underwent comprehensive genome profiling (CGP), which led to the detection of a CTNNA1 GPV (p.Q662*). His gastric cancer tissues demonstrated a loss of α-1 catenin expression. His mother with a history of gastric signet-ring cell carcinoma had undergone genetic counseling 2 years ago, because of her broad family history of young-onset gastric cancer. Then, she had undergone germline multigene panel testing (MGPT) that included CDH1 but not CTNNA1, and no GPV had been detected. Here, Japanese precision cancer medicine revealed a GPV of a gene rarely associated with HDGC, that could not be detected by common MGPTs.

Indexed as

alpha CateninGerm-Line MutationStomach NeoplasmsAdultEast Asian PeopleFemaleGenetic Predisposition to DiseaseHumansJapanMalePedigreealpha CateninCTNNA1 protein, humanCTNNA1Genetic counselingGermline findingHereditary diffuse-type gastric cancer (HDGC)

Identifiers

PMID39838246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.