Evidence map›Paper›PMID 39838233›Full record

ArticleMolecular imaging and biology2025

PET Imaging of a Transgenic Tau Rat Model SHR24 with [

Nisha K Ramakrishnan, Annie Ziyi Zhao, Stephen Thompson, Selena Milicevic Sephton, David J Williamson, Tomáš Smolek, Norbert Žilka, Franklin I Aigbirhio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nisha K RamakrishnanMolecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK. nk473@cam.ac.uk.ORCID http://orcid.org/0000-0003-2189-1941
Annie Ziyi ZhaoMolecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0009-0000-2002-370X
Stephen ThompsonMolecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0003-3596-7812
Selena Milicevic SephtonMolecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0002-1105-6726
David J WilliamsonMolecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
Tomáš SmolekAxon Neuroscience R&D Services SE, Dubravska vćesta 9, 811 02, Bratislava, Slovakia.ORCID http://orcid.org/0000-0002-1959-0069
Norbert ŽilkaAxon Neuroscience R&D Services SE, Dubravska vćesta 9, 811 02, Bratislava, Slovakia.ORCID http://orcid.org/0000-0003-2397-2083
Franklin I AigbirhioMolecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0001-9453-5257

Funding

MRC Proximity to Discovery: Industry Engagement Fund of University of Cambridge Biomedical Research Exchange Programme RG89685 #14921
6 · The paper itself

Abstract

purposePositron Emission Tomography (PET) scans with radioligands targeting tau neurofibrillary tangles (NFT) have accelerated our understanding of the role of misfolded tau in neurodegeneration. While intended for human research, applying these radioligands to small animals establishes a vital translational link. Transgenic animal models of dementia, such as the tau rat SHR24, play a crucial role in enhancing our understanding of these disorders. This study aims to evaluate the utility of SHR24 rat model for PET studies. PROCEDURES: Dynamic PET scans were conducted in male SHR24 rats and their wild-type SHR (SHRwt) littermates using [

resultsTotal distribution volume (V

conclusionsWith the ability to detect binding of established radioligand [

Indexed as

Fluorine RadioisotopesPositron-Emission Tomographytau ProteinsAnimalsBrainDisease Models, AnimalMaleRatsRats, Inbred SHRRats, TransgenicTissue DistributionFluorine Radioisotopestau ProteinsAutoradiographyKinetic modellingPositron emission tomographyReference tissue modelTau rat

Identifiers

PMID39838233
PMCPMC12062146

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.