Evidence map›Paper›PMID 39838211›Full record

ArticleMycopathologia2025

Epidemiology of Coronavirus Disease 2019-Associated Fungal Infections in the Intensive Care Unit: A Single-Center Retrospective Study.

Jessica S Little, Gerald McGwin, Lisa Tushla, Kaitlin Benedict, Meghan M Lyman, Mitsuru Toda, John W Baddley, Peter G Pappas

Abstract read
PubMed Publisher
In one paragraph

Article in Mycopathologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jessica S LittleDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. jlittle@bwh.harvard.edu.ORCID https://orcid.org/0000-0001-8093-5647
Gerald McGwinDivision of Infectious Diseases, University of Alabama, The University of Alabama at Birmingham, Birmingham, AL, USA.
Lisa TushlaTerranova Medica, LLC, Colorado Springs, CO, USA.
Kaitlin BenedictCenters for Disease Control and Prevention, Atlanta, GA, USA.
Meghan M LymanCenters for Disease Control and Prevention, Atlanta, GA, USA.
Mitsuru TodaCenters for Disease Control and Prevention, Atlanta, GA, USA.
John W BaddleyDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-9111-625X
Peter G PappasDivision of Infectious Diseases, University of Alabama, The University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

NCEZID CDC HHS CDC-RFA-CK20-2003
6 · The paper itself

Abstract

introductionInvasive fungal disease (IFD) is a morbid superinfection that can arise in critically ill patients with COVID-19 infection. Studies evaluating the full spectrum of COVID-19-associated fungal infections remain limited.

methodsSingle-center retrospective study assessing IFD in patients with COVID-19, hospitalized for ≥ 72 h in the intensive care unit (ICU) between 02/25/20 and 02/28/22 (n = 1410). IFD was assessed using consensus criteria (EORTC/MSGERC or ISHAM/ECMM criteria). T- and chi-square tests compared demographic/clinical characteristics between IFD and non-IFD patients. Cox proportional hazards regression estimated risk factors for in-hospital mortality.

resultsOf 1410 patients with severe COVID-19, 70 (5%) had a diagnosis of COVID-19-associated fungal infection with invasive candidiasis occurring in 3%, and invasive aspergillosis in 2%. Other fungal infections were rare. Patients with IFD had longer ICU stays (26 vs. 13 days; p < 0.001); increased rates of mechanical ventilation (99% vs. 70%; p < 0.001); and a higher risk of in-hospital death (69% vs. 36%; p < 0.001). On multivariable analysis, COVID-associated fungal infections were associated with an increased risk of in-hospital mortality.

conclusionsThis real-world study of critically ill patients with COVID-19 demonstrated a low incidence of COVID-19-associated fungal infections with invasive candidiasis occurring most frequently. Fungal infections were associated with an increased risk of in-hospital mortality in this population.

Indexed as

COVID-19Intensive Care UnitsInvasive Fungal InfectionsMycosesAdultAgedAged, 80 and overCritical IllnessFemaleHospital MortalityHumansMaleMiddle AgedRetrospective StudiesRisk FactorsSARS-CoV-2COVID-19-associated CandidiasisCOVID-19-associated pulmonary AspergillosisInvasive fungal diseaseSevere COVID-19

Identifiers

PMID39838211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.