Evidence map›Paper›PMID 39838166›Full record

ArticleJournal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie2025

The IL-17 level in gingival crevicular fluid as an indicator of orthodontically induced inflammatory root resorption.

Honghong Zhang, Lufei Wang, Aipeng Liu, Hua Zhou, Xiao Liang, Na Kang

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Article in Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Honghong ZhangGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction & Department of Orthodontics, College and Hospital of Stomatology, Guangxi Medical University, 10 Shuangyong Road, 530021, Nanning, Guangxi, China.
Lufei WangGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction & Department of Orthodontics, College and Hospital of Stomatology, Guangxi Medical University, 10 Shuangyong Road, 530021, Nanning, Guangxi, China.
Aipeng LiuGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction & Department of Orthodontics, College and Hospital of Stomatology, Guangxi Medical University, 10 Shuangyong Road, 530021, Nanning, Guangxi, China.
Hua ZhouGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction & Department of Orthodontics, College and Hospital of Stomatology, Guangxi Medical University, 10 Shuangyong Road, 530021, Nanning, Guangxi, China.
Xiao LiangGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction & Department of Orthodontics, College and Hospital of Stomatology, Guangxi Medical University, 10 Shuangyong Road, 530021, Nanning, Guangxi, China.
Na KangGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction & Department of Orthodontics, College and Hospital of Stomatology, Guangxi Medical University, 10 Shuangyong Road, 530021, Nanning, Guangxi, China. kangna05@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInterleukin (IL)-17 expression in the periodontal ligament is associated with orthodontically induced inflammatory root resorption (OIIRR). Seeking a convenient, rapid, and non-invasive IL-17 detection approach could help predict OIIRR. In this study, we assessed the potential of the IL-17 level in gingival crevicular fluid (GCF) to be an indicator of OIIRR.

methodsTo enable tooth movement, 8‑ to 10-week-old male Wistar rats were subjected to 20 g/60 g orthodontic force for up to 14 days. GCF and peripheral blood were collected for the IL-17 enzyme-linked immunosorbent assay (ELISA). Histological changes and the expression of IL-17, receptor activator of nuclear factor κB ligand (RANKL), and osteoprotegerin (OPG) in periodontal tissue were evaluated by hematoxylin-eosin and immunohistochemistry staining, respectively. Osteoclasts were visualized by tartrate-resistant acid phosphatase (TARP) staining.

resultsGCF IL-17 level rapidly rose in the early phase of orthodontic loading, accompanied by bone and tooth root destruction. At the later stage, the GCF IL-17 level gradually decreased, while the inflammatory destruction was reduced and the periodontal tissue began to repair. GCF IL-17 expression generally tended to be coincident with the periodontal tissue reaction: GCF IL-17 was robustly correlated to the RANKL/OPG ratio (r

conclusionThe IL-17 level in GCF during orthodontic treatment is associated with OIIRR and, thus, could be an early indicator for developing OIIRR. The advantages of being a convenient, rapid, and non-invasive GCF IL-17 measurement make it a promising method for early detection of OIIRR.

Indexed as

Gingival Crevicular FluidInterleukin-17Root ResorptionTooth Movement TechniquesAnimalsBiomarkersMaleRatsRats, WistarSensitivity and SpecificityBiomarkersInterleukin-17Animal modelsClinical early warning signsInterleukin-17Orthodontic tooth movementPeriodontal ligament

Identifiers

PMID39838166

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