ArticleSurgical endoscopy2025
Self-gripping versus polypropylene mesh for incisional hernia repair in a rat model.
Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundSelf-gripping mesh, made of monofilament polypropylene and covered by a layer of polylactic acid micro-hooks, is applied in ventral hernia repair, whereas cytological change and collagen expression around the mesh are rarely reported. The objective of this research was to compare inflammatory response and collagen proliferation between self-gripping and polypropylene mesh in rat model of incisional hernia.
methodsForty-five rats were randomly divided into unrepaired (UR) group, polypropylene (PP) mesh group, and self-gripping (SG) mesh group and euthanized at 1, 2 and 4 weeks postoperatively. The levels of inflammation, neovascularization, and collagen expression were measured by immunohistochemistry, quantitative real-time polymerase chain reaction, and Western blot.
resultsOne rat died and others developed typical incisional hernia in UR group, and hematoma, seroma, or wound infection were not observed in PP and SG groups. There was no significant difference in mesh shrinkage and inflammatory infiltration between PP and SG groups. With regard to neovascularization, 2 groups were comparable at 1 and 2 weeks, while the neovascularization score of PP group was statistically higher than that of SG group at 4 weeks. One week after surgery, the amounts of Collagen I (Col I) mRNA in PP group were significantly higher than SG group, while the amounts of Collagen III (Col III) mRNA were comparable between 2 groups. Two weeks following operation, the expressions of Col I mRNA and Col III mRNA in PP group were statistically lower than those in SG group. Four weeks postoperatively, the levels of Col I mRNA and Col III mRNA in PP group were significantly higher than those in SG group.
conclusionSelf-gripping mesh induced comparable inflammatory response and collagen proliferation compared with polypropylene mesh in a rat model. REGISTRATION NUMBER: ZZU-LAC2023080121.
Indexed as
Identifiers
39838148What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.