ArticleEuropean radiology2025
Left atrial functional impairment as a predictor of atrial fibrillation: insights from cardiac CT.
Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Left atrial strain on 2D-STE in pediatric dilated cardiomyopathy.Echo research and practice · 2026Article
- Development and Internal Validation of a Diagnostic Nomogram for Identifying Left Atrial Enlargement in Patients with Essential Hypertension.International journal of general medicine · 2026Article
- Ubiquitin-specific protease 38 modulates atrial fibrillation susceptibility in chronic kidney disease via STRAP stabilization and activation of TGF-β/SMAD signaling.Molecular medicine (Cambridge, Mass.) · 2025Article
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4 authors.
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Abstract
objectivesA strong association exists between left atrial (LA) structural remodeling and the development of atrial fibrillation (AF). The role of LA function in AF prediction remains unclear. We studied the relationship between LA function and incident AF using cardiac CT. MATERIALS AND
methodsWe retrospectively analyzed patients who underwent multiphasic cardiac CT. LA volumes and parameters of LA global, reservoir and booster function were calculated. The association between measures of LA function and incident AF was analyzed using multivariable Cox regression adjusting for clinical variables, LA volume and left ventricular function.
results1025 patients (age 64 years ± 14) were evaluated. Over a median of 3.9 years, 90 patients developed AF. There was a significant association between LA total emptying fraction (adjusted hazard ratio (HR) 1.05; 95% CI: 1.02-1.05 per 1% decrease, p < 0.001), LA reservoir function (HR 1.04; 95% CI: 1.02-1.06 per 1 mL/m
conclusionLA functional impairment is common even in patients with normal LA volume and provides additional prognostic information for AF risk. The findings underscore the significance of LA mechanical dysfunction in the pathogenesis of AF. KEY POINTS: Question A strong association exists between left atrial structural remodeling and incident atrial fibrillation. The role of left atrial function in atrial fibrillation prediction remains unclear. Findings Left atrial reservoir and passive emptying function (but not booster function) predict incident atrial fibrillation independent of left atrial volume and clinical risk factors. Clinical relevance Left atrial functional impairment precedes the development of atrial fibrillation. Measures of left atrial reservoir and passive emptying function are independent predictors of incident atrial fibrillation.
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