Evidence map›Paper›PMID 39838039›Full record

ArticleScientific reports2025

Molecular epidemiology and genetic diversity of disappearing Plasmodium vivax in southern Thailand.

Parsakorn Tapaopong, Gustavo da Silva, Aurel Holzschuh, Wasinee Rungsarityotin, Chayanut Suansomjit, Kanit Pumchuea, Khajohnpong Manopwisedjaroen, Amnat Khamsiriwatchara, Podjadeach Khuntong, Liwang Cui and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. UnderstandingiScience · 2026
    Article
  4. Article
  5. UnderstandingmedRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Parsakorn TapaopongMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Gustavo da SilvaDepartment of Biological Sciences, Eck Institute for Global Health, Galvin Life Sciences, University of Notre Dame, Notre Dame, IN, USA.
Aurel HolzschuhDepartment of Medicine, Swiss Tropical and Public Health Institute, Allschwil, Switzerland.
Wasinee RungsarityotinMahidol University Frontier Research Facility, Mahidol University, Salaya, Nakhon Pathom, Thailand.
Chayanut SuansomjitMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Kanit PumchueaMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Khajohnpong ManopwisedjaroenMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Amnat KhamsiriwatcharaFaculty of Tropical Medicine, Center of Excellence for Biomedical and Public Health Informatics (BIOPHICS), Mahidol University, Bangkok, Thailand.
Podjadeach KhuntongFaculty of Tropical Medicine, Center of Excellence for Biomedical and Public Health Informatics (BIOPHICS), Mahidol University, Bangkok, Thailand.
Liwang CuiDivision of Infectious Diseases and International Medicine, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Cristian KoepfliDepartment of Biological Sciences, Eck Institute for Global Health, Galvin Life Sciences, University of Notre Dame, Notre Dame, IN, USA.
Jetsumon SattabongkotMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Wang NguitragoolMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. wang.ngu@mahidol.edu.

Funding

Southeast Asia Malaria Research CenterU19AI089672 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CUI, LIWANG · 2010 to 2023
$28.9M
The changing landscape of human and zoonotic malaria in Southeast AsiaU19AI181583 · NIAID · MAHIDOL UNIVERSITY · PI Amnat Khamsiriwatchara · 2024 to 2026
$3.6M
National Science Research and Innovation Fund Mahidol University Fundamental Fund: fiscal year 2023NIAID NIH HHS U19 AI089672NIAID NIH HHS U19 AI181583
6 · The paper itself

Abstract

The evolution of genetic diversity and population structure of Plasmodium vivax as malaria elimination approaches remains unclear. This study analyzed the genetic variation and molecular epidemiology of P. vivax from Yala Province in southern Thailand, an area in the pre-elimination phase. Seventy P. vivax isolates, collected between 2017 and 2020, were genotyped for domain II of pvdbp and the 42-kDa region of pvmsp1 using amplicon deep sequencing. Data from Yala province were compared to published data from Tak province, where transmission was higher. Key analyses included nucleotide diversity (π), haplotype diversity (Hd), natural selection, recombination rates, and complexity of infection (COI). Genetic diversity in Yala was relatively low (π = 0.008

Indexed as

Genetic VariationMalaria, VivaxPlasmodium vivaxGenotypeHaplotypesHumansMaleMerozoite Surface Protein 1Molecular EpidemiologyPhylogenyProtozoan ProteinsThailandMerozoite Surface Protein 1Protozoan ProteinsAmplicon sequencingDuffy binding proteinGenetic diversityMalariaMerozoite surface protein-1Plasmodium vivax

Identifiers

PMID39838039
PMCPMC11751107

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.