SynthesisPediatric research2025
Early age of dog exposure is negatively associated with atopic dermatitis: A comprehensive analysis.
Synthesis in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The role of dog keeping in the home microbiota and its impact on children's health.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, whether exposure to pets is a protective factor for atopic dermatitis (AD) is controversial.
objectiveTo investigate the association of pet exposure in early life with the incident AD.
methodsThis study was based on PRISMA. The authors independently searched PubMed, Cochrane Library, and EMBASE. We gathered cohort studies reporting on the ratio of pet exposure and incident AD and meta-analyzed them by relative risks (RRs) and 95% confidence interval (CI). Newcastle-Ottawa Scale (NOS) and funnel plot were performed to evaluate the quality of the study and publication bias, respectively. P < 0.05 was considered statistically significant.
resultsWe included 23 studies comprising 3174-25,527 participants with exposure age 0-12. The quality of included studies was generally gorgeous, with NOS 5-8. Dog exposure was negatively associated with the incident AD, with RRs of 0.82 (P = 0.002), but this trend was insignificant in cats (RR = 1.08; P = 0.490) and other pets (RR = 0.94; P = 0.550). Subgroup analysis showed participants exposed to dogs had a further lower AD risk in the North American populations (RR = 0.60; P < 0.001). Publication bias was not supported by the funnel plot.
conclusionThis study finds exposure to dog pets in early life is negatively associated with newly developed AD, especially in North American populations. IMPACT: Currently, whether exposure to pets is a protective factor for atopic dermatitis (AD) is controversial. This study finds exposure to dog pets in early life is negatively associated with newly developed atopic dermatitis, and this trend is more remarkable in North American populations. Associations of exposure to cats and other pets with atopic dermatitis are not found. These results discover a novel insights to prevention AD and related diseases.
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Registered trials
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