Evidence map›Paper›PMID 39837950›Full record

ArticleScientific reports2025

Evaluation of hesperidin as a potential larvicide against Culex pipiens with computational prediction of its mode of action via molecular docking.

Abdullah Haikal, Mahmoud Kamal, Eslam M Hosni, Yhiya Amen

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Gustatory sensing by ovipositor drives maternal avoidance of hesperidin to benefit the offspring in a major agricultural fly pest.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abdullah HaikalDepartment of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.ORCID 0000-0003-2548-3507
Mahmoud KamalDepartment of Entomology, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt. mkasu@sci.asu.edu.eg.ORCID 0000-0001-7447-0433
Eslam M HosniDepartment of Entomology, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt.ORCID 0000-0002-5657-704X
Yhiya AmenDepartment of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.ORCID 0000-0003-2552-4567

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hesperidin, a natural flavanone glycoside predominantly found in citrus fruits, has gained attention for its wide-ranging biological activities, including potential insecticidal properties. Culex pipiens, commonly known as the northern house mosquito, is a major vector of several human pathogens, such as the West Nile virus and filariasis, making it a key target in the fight against vector-borne diseases. In this study, we evaluated the larvicidal activity of Hesperidin against Culex pipiens larvae, assessing its potential as an alternative to chemical insecticides. Hesperidin demonstrated potent larvicidal effects, with a lethal concentration 50 (LC

Indexed as

CulexHesperidinInsecticidesAcetylcholinesteraseAnimalsLarvaMolecular Docking SimulationAcetylcholinesteraseHesperidinInsecticidesAcetylcholinesterase inhibitionCulex pipiensFlavanone glycosideHesperidinLarvicidal activityMolecular dockingNatural insecticideVector control

Identifiers

PMID39837950
PMCPMC11751293

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.