Evidence map›Paper›PMID 39837940›Full record

ArticleScientific reports2025

Development of a 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis.

Stratos Vassis, Mia Glerup, Ida Tambjerg, Annelise Küseler, Cory M Resnick, Carlalberta Verna, Troels Herlin, Lillemor Berntson, Charlotte Myrup, Ellen Nordal and 5 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Stratos VassisSection of Orthodontics, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. stratos.vassis@dent.au.dk.
Mia GlerupDepartment of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Ida TambjergSection of Orthodontics, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.
Annelise KüselerSection of Orthodontics, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.
Cory M ResnickHarvard Medical School and Harvard School of Dental Medicine; Department of Oral and Maxillofacial Surgery, Boston Children's Hospital, Boston, USA.
Carlalberta VernaDepartment of Paediatric Oral Health and Orthodontics, University Center of Dental Medicine UZB, University of Basel, Basel, Switzerland.
Troels HerlinDepartment of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Lillemor BerntsonDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Charlotte MyrupDepartment of Pediatrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Ellen NordalDepartment of Pediatrics, University Hospital of North Norway, Tromsö, Norway.
Marite RyggDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Kristiina AaltoDepartment of Pediatrics, New Children's Hospital, Helsinki University Hospital, University of Helsinki and Pediatric Research Center, Helsinki, Finland.
Sven Erik NoerholtDepartment of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark.
Thomas K PedersenSection of Orthodontics, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.
Peter StoustrupSection of Orthodontics, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This investigation aimed to develop a radiographic 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis (JIA), and to perform a validation against expert evaluations. Data were collected from a population-based Nordic JIA cohort of 240 patients that received a cone-beam computed tomography (CBCT) scan approximately 17 years after onset of JIA. The cohort was randomized into two groups: A baseline group for establishing the index (n = 210) and a test group (n = 30). The standardized index generation process led to the inclusion of six radiographic outcome measures, each representing different facets of dentofacial deformities. Specific severity scores were established for three domains; dentofacial asymmetry (0-8), vertical deviation (0-8), and sagittal deviation (0-8). An overall dentofacial deformity index score was computed by aggregating the scores from the six variables, with the total score ranging from 0 to 24. The validity of the index was assessed by comparing the index score with expert evaluations. Based on the generated index, 10 patients exhibited severe deformities. Reliable agreement between data-generated index scores and expert assessments was found. A 3D radiographic dentofacial deformity index was generated and tested. This index can support an objective assessment of the severity of dentofacial deformities related to JIA in a clinical setting and future research.

Indexed as

Arthritis, JuvenileCephalometryDentofacial DeformitiesImaging, Three-DimensionalAdolescentChildChild, PreschoolCone-Beam Computed TomographyFemaleHumansMaleSeverity of Illness Index

Identifiers

PMID39837940
PMCPMC11750957

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