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ArticleScientific reports2025

Serum levels of Wnt5a in Egyptian women with obesity and their association with toll like receptor 2 Arg753Gln gene polymorphism in a pilot case control study of obesity as a state of metaflammation.

Shaimaa H Fouad, Mai Eldeeb, Shereen A Baioumy, Sara I Taha, Rehab Ali Ibrahim, Aya Elgendy, Azza Omran, Marwa Hamdy, Raed A Alharbi, Abdulmajeed A A Sindi and 1 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Shaimaa H FouadDepartment of Internal Medicine /Allergy and Clinical Immunology, Ain- Shams University, Cairo, Egypt.
Mai EldeebDepartment of Internal Medicine /Allergy and Clinical Immunology, Ain- Shams University, Cairo, Egypt.
Shereen A BaioumyDepartment of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Sara I TahaDepartment of Clinical Pathology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt. dr_sara_ib@med.asu.edu.eg.ORCID 0000-0001-8224-8701
Rehab Ali IbrahimDepartment of Physical Medicine/Rheumatology and Rehabilitation, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Aya ElgendyDepartment of Internal Medicine /Allergy and Clinical Immunology, Ain- Shams University, Cairo, Egypt.
Azza OmranDepartment of Cardiology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Marwa HamdyDepartment of Medical Biochemistry and Molecular Biology, Ain-Shams University, Cairo, Egypt.
Raed A AlharbiDepartment of Laboratory Medicine, Faculty of Applied Medical Sciences, Al-Baha University, Albaha, Kingdom of Saudi Arabia.
Abdulmajeed A A SindiDepartment of Basic Medical Sciences, Faculty of Applied Medical Sciences, Al-Baha University, Albaha, Kingdom of Saudi Arabia.
Sylvia W RomanDepartment of Internal Medicine /Allergy and Clinical Immunology, Ain- Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Female obesity is a worldwide health issue linked to chronic metabolic low-grade inflammation (metaflammation) causing multiple obesity-related co-morbid conditions. We aimed to assess the serum levels of wingless integration site family member 5 A (Wnt5a), leptin, and tumor necrosis factor-alpha (TNF-α) as markers of obesity-associated metaflammation and investigate the association with toll-like receptors2 (TLR2) gene (Arg753Gln) single nucleotide polymorphism (SNP) among Egyptian females. The study included 60 females with obesity and 30 matched controls. Serum levels of Wnt5a, leptin, and TNF-α were assessed by ELISA, while TLR2 (Arg753Gln) genotyping was done by PCR-RFLP. Serum Wnt5a, leptin, and TNF-α showed significantly higher levels in females with obesity than controls and a significant increase with higher classes of obesity. They showed significant positive correlations with each other. Only TNF-α and leptin were associated with metabolic syndrome (MetS) among the obesity group. According to TLR2 (Arg753Gln) SNP, the homozygous GG genotype was associated with elevated levels of Wnt5a, leptin, and TNF-α compared to the AA + GA model carriers. No significant differences were found in the distribution of TLR2 Arg753Gln (rs5743708) genotypes and alleles according to obesity or MetS, and the regression analysis showed no significant risk association. Serum Wnt5a, leptin, and TNF-α levels increase in women with obesity and the A allele of TLR2 (Arg753Gln) SNP could be protective against obesity-associated metaflammation.

Indexed as

InflammationObesityPolymorphism, Single NucleotideToll-Like Receptor 2Wnt-5a ProteinAdultCase-Control StudiesEgyptFemaleGenetic Predisposition to DiseaseGenotypeHumansLeptinMiddle AgedPilot ProjectsTumor Necrosis Factor-alphaLeptinTLR2 protein, humanToll-Like Receptor 2Tumor Necrosis Factor-alphaWnt-5a ProteinWNT5A protein, humanInflammationLeptinMetabolic syndromeObesityTLR2TNF-αWnt5a

Identifiers

PMID39837875
PMCPMC11751074

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