Evidence map›Paper›PMID 39837553›Full record

ArticleThrombosis and haemostasis2025

Psychometric Validation of the Hemophilia Functional Ability Scoring Tool (Hemo-FAST).

Virginie Barbay, Yohann Repessé, Dominique Desprez, Nicolas Drillaud, Birgit Frotscher, Marie-Léa Piel-Julian, Sabine Castet, Fabienne Genre-Volot, Brigitte Tardy, Annie Harroche and 7 more

Registry-linked trialAbstract readValidation StudyMulticenter Study
In one paragraph

Article in Thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04731701 (Psychometric Validation of the Hemophilia Functional Ability Scoring Tool), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04731701 completednot on this map

Psychometric Validation of the Hemophilia Functional Ability Scoring Tool (Hemo-FAST)

TypeobservationalSponsorSwedish Orphan BiovitrumRan2021 to 2022Enrolled180ConditionsHemophilia A, Hemophilia BArmsHemophilia Joint Health Score (HJHS)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Virginie BarbayHaemophilia Treatment Centre, University Hospital of Rouen Normandie, Rouen, France.
Yohann RepesséHaemophilia Treatment Centre CRC-MHC, University Hospital of Caen Normandie, Caen, France.
Dominique DesprezHaemophilia Treatment Centre, CHU Strasbourg, Strasbourg, France.
Nicolas DrillaudHaemophilia Treatment Centre CRC-MHC, University Hospital, Nantes, France.
Birgit FrotscherHaemophilia Treatment Centre, University Hospital, Nancy, France.
Marie-Léa Piel-JulianHaemophilia Treatment Center, University Hospital, Toulouse, France.
Sabine CastetHaemophilia Treatment Centre, University Hospital, Bordeaux, France.
Fabienne Genre-VolotHaemophilia Treatment Centre, University Hospital, Dijon, France.
Brigitte TardyCRC Hémophilie, CIC Inserm 1408 CHU St Etienne, France.
Annie HarrocheCentre de Ressources et de Compétences Maladies Hémorragiques Constitutionnelles, Hôpital Universitaire Necker-Enfants Malades, Paris, France.
Corinne GandossiMedical Affairs, Sobi, Paris, France.
Meriem ZidiMedical Affairs, Sobi, Paris, France.
Sara CarlssonClinical Study Management, Sobi, Stockholm, Sweden.
Nana KraghGlobal HEOR, Sobi, Stockholm, Sweden.
Eva BednarGlobal Medical Affairs and Clinical Development, Sobi, Stockholm, Sweden.
Claude NégrierUniversity Lyon 1, Lyon, France.
Aurélien LebretonCentre de Ressources et Compétences des Maladies Hémorragiques Constitutionnelles, CHU Clermont-Ferrand, Estaing Hospital, Clermont-Ferrand, France.

Funding

Sobi NCT04731701
6 · The paper itself

Abstract

The Hemophilia Functional Ability Scoring Tool (Hemo-FAST), consisting of a patient-reported outcome (PRO) part and a clinician-reported outcome (ClinRO) part, was developed as a rapid and effective tool to assess functional mobility in clinical practice. This study (NCT04731701) aimed to validate the psychometric properties of Hemo-FAST for assessment of joint health in people with haemophilia (PwH).PwH A or B aged ≥18 years completed questionnaires including the PRO part of Hemo-FAST and the short-form 36 health survey (SF-36) during one study visit. Clinicians completed the Haemophilia Joint Health Score (HJHS) and the ClinRO part of Hemo-FAST at the same visit. Validation was performed using reliability, construct validity, and structure validity assessments.The study enrolled 180 PwH A or B from 14 centres across France. Estimated time to complete the PRO part was mean (standard deviation) 4.6 (5.4) minutes. PRO items showed good test-retest reliability (intraclass correlation coefficient value ≥0.70). Inter-rater values were >0.70 for 7/9 ClinRO items, indicating good reliability. All items (15 PRO; 9 ClinRO) had high internal consistency (Cronbach's coefficient alpha: 0.97). Hemo-FAST demonstrated convergent construct validity with HJHS and the SF-36 physical component and discriminant construct validity with the SF-36 mental health component. Hemo-FAST scores distinguished between subgroups of people with expected differences in joint health status, including by haemophilia severity (

Indexed as

Hemophilia AHemophilia BPatient Reported Outcome MeasuresPsychometricsAdolescentAdultAgedDisability EvaluationFemaleFranceFunctional StatusHumansMaleMiddle AgedPredictive Value of TestsQuality of Life

Identifiers

PMID39837553
PMCPMC12457003

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.