Evidence map›Paper›PMID 39837498›Full record

ArticleOpen biology2025

The role of KLF4 in human primordial germ cell development.

Sun-Min Lee, Merrick Pierson Smela, M Azim Surani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mechanisms of human germ cell development.Nature reviews. Molecular cell biology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sun-Min LeeGurdon Institute, Tennis Court Road, University of Cambridge, Cambridge CB2 1QN, UK.ORCID 0000-0001-8435-2430
Merrick Pierson SmelaGurdon Institute, Tennis Court Road, University of Cambridge, Cambridge CB2 1QN, UK.
M Azim SuraniGurdon Institute, Tennis Court Road, University of Cambridge, Cambridge CB2 1QN, UK.

Funding

BBSRCNational Research Foundation of Korea
6 · The paper itself

Abstract

Primordial germ cells (PGCs) are the founder cells that develop into mature gametes. PGCs emerge during weeks 2-3 of human embryo development. Pluripotency genes are reactivated during PGC specification, including Krüppel-like factor KLF4, but its precise role in PGC development is unclear. Here, we investigated the role of KLF4 in PGC development using our

Indexed as

Germ CellsKruppel-Like Transcription FactorsCell DifferentiationGene Expression ProfilingGene Expression Regulation, DevelopmentalHumansKruppel-Like Factor 4TranscriptomeKLF4 protein, humanKruppel-Like Factor 4Kruppel-Like Transcription FactorsKLF4pluripotency factorsprimordial germ cellsstem cells

Identifiers

PMID39837498
PMCPMC11750398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.