ArticleJournal of the Royal Society, Interface2025
Tissue stresses caused by invasive tumour: a biomechanical model.
Article in Journal of the Royal Society, Interface, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tissue stresses caused by invasive tumour: a biomechanical model.Journal of the Royal Society, Interface · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Malignant tumorigenesis is a complex process involving growth, invasion and mechanical deformation of a cancerous tissue. In this paper, a biomechanical model is proposed to couple the mechanical and biological mechanisms governing invasive tumour development. As an example, this model is applied to investigate the spatio-temporal evolution of tissue stresses in an invasive tumour spheroid and its host tissue. I show that cancer invasiveness lowers the compressive tissue stresses and blurs the stress distribution across the cancerous-normal tissue boundary, both consistent with experimental observations. Importantly, with the steady propagation of the cancerous region driven by persistent cancer invasion, tumour stresses are predicted to saturate rather than keep increasing as in benign tumour growth. The model is further used to analyse the deformation and stress state of a cancerous tissue being cut into two pieces, and reproduces the bulge of the cut surface observed in experiments. I hope this study can pave the way for the quantitative evaluation of mechanical states in cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.