Evidence map›Paper›PMID 39836952›Full record

ArticleJMIR research protocols2025

Applications of Natural Language Processing and Large Language Models for Social Determinants of Health: Protocol for a Systematic Review.

Swati Rajwal, Ziyuan Zhang, Yankai Chen, Hannah Rogers, Abeed Sarker, Yunyu Xiao

Abstract read
In one paragraph

Article in JMIR research protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. The Accuracy And Clinical Relevance of Chat GPT-4 in Triple Negative Breast Cancer Research.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Swati RajwalDepartment of Computer Science, Emory University, Atlanta, GA, United States.ORCID 0000-0002-3826-5069
Ziyuan ZhangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States.ORCID 0000-0003-3488-5903
Yankai ChenDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.ORCID 0000-0001-5741-2047
Hannah RogersWoodruff Health Sciences Center Library, Emory University, Atlanta, GA, United States.ORCID 0000-0002-9515-1439
Abeed SarkerDepartment of Biomedical Informatics, Emory University, Atlanta, GA, United States.ORCID 0000-0001-7358-544X
Yunyu XiaoDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.ORCID 0000-0002-0479-1781

Funding

Leveraging Longitudinal Survey and EHR data to Dissect the Impact of COVID-19 related Stressors and Infections on Child Mental Health and Suicide RisksRF1MH134649 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI XIAO, YUNYU · 2023 to 2023
$3.2M
Mining Social Media Big Data for Toxicovigilance: Studying Substance Use via Natural Language Processing and Machine Learning MethodsR01DA057599 · NIDA · EMORY UNIVERSITY · PI Abeed H Sarker · 2022 to 2026
$2.2M
NIDA NIH HHS R01 DA057599NIMH NIH HHS RF1 MH134649
6 · The paper itself

Abstract

backgroundIn recent years, the intersection of natural language processing (NLP) and public health has opened innovative pathways for investigating social determinants of health (SDOH) in textual datasets. Despite the promise of NLP in the SDOH domain, the literature is dispersed across various disciplines, and there is a need to consolidate existing knowledge, identify knowledge gaps in the literature, and inform future research directions in this emerging field.

objectiveThis research protocol describes a systematic review to identify and highlight NLP techniques, including large language models, used for SDOH-related studies.

methodsA search strategy will be executed across PubMed, Web of Science, IEEE Xplore, Scopus, PsycINFO, HealthSource: Academic Nursing, and ACL Anthology to find studies published in English between 2014 and 2024. Three reviewers (SR, ZZ, and YC) will independently screen the studies to avoid voting bias, and two (AS and YX) additional reviewers will resolve any conflicts during the screening process. We will further screen studies that cited the included studies (forward search). Following the title abstract and full-text screening, the characteristics and main findings of the included studies and resources will be tabulated, visualized, and summarized.

resultsThe search strategy was formulated and run across the 7 databases in August 2024. We expect the results to be submitted for peer review publication in early 2025. As of December 2024, the title and abstract screening was underway.

conclusionsThis systematic review aims to provide a comprehensive study of existing research on the application of NLP for various SDOH tasks across multiple textual datasets. By rigorously evaluating the methodologies, tools, and outcomes of eligible studies, the review will identify gaps in current knowledge and suggest directions for future research in the form of specific research questions. The findings will be instrumental in developing more effective NLP models for SDOH, ultimately contributing to improved health outcomes and a better understanding of social determinants in diverse populations. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/66094.

Indexed as

Natural Language ProcessingSocial Determinants of HealthHumansLarge Language ModelsResearch DesignSystematic Reviews as Topiclarge language modelsLLMnatural language processingNLPSDOHsocial determinants of healthsystematic review protocol

Identifiers

PMID39836952
PMCPMC11795155

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.