Evidence map›Paper›PMID 39836754›Full record

ArticleCirculation2025

ADMET-AI Enables Interpretable Predictions of Drug-Induced Cardiotoxicity.

Souhrid Mukherjee, Kyle Swanson, Parker Walther, Rabindra V Shivnaraine, Jeremy Leitz, Paul D Pang, James Zou, Joseph C Wu

Abstract readLetter
In one paragraph

Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Target discovery and drug design in the era of artificial intelligence.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Integrated UHPLC-QTOF-MSJournal of computer-aided molecular design · 2026
    Article
  10. Article
  11. Review
  12. Review
  13. The Five-Decade Journey of Small Cell Lung Cancer.Cancer communications (London, England) · 2026
    Review
  14. Review
  15. Article
  16. Cardiac fibrosis: from mechanisms and models to medicines.Trends in pharmacological sciences · 2025
    Review
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Souhrid Mukherjee *Stanford Cardiovascular Institute (S.M., R.V.S., P.D.P., J.C.W.), Stanford University, CA.ORCID 0000-0002-8355-3000
Kyle Swanson *Departments of Computer Science (K.S., J.Z.), Stanford University, CA.ORCID 0000-0002-7385-7844
Parker WaltherGreenstone Biosciences, Palo Alto, CA (S.M., K.S., P.W., R.V.S., J.L., P.D.P.).
Rabindra V ShivnaraineStanford Cardiovascular Institute (S.M., R.V.S., P.D.P., J.C.W.), Stanford University, CA.ORCID 0000-0002-1478-5422
Jeremy LeitzGreenstone Biosciences, Palo Alto, CA (S.M., K.S., P.W., R.V.S., J.L., P.D.P.).ORCID 0009-0009-9976-2497
Paul D PangStanford Cardiovascular Institute (S.M., R.V.S., P.D.P., J.C.W.), Stanford University, CA.
James Zou *Departments of Computer Science (K.S., J.Z.), Stanford University, CA.ORCID 0000-0001-8880-4764
Joseph C Wu *Stanford Cardiovascular Institute (S.M., R.V.S., P.D.P., J.C.W.), Stanford University, CA.ORCID 0000-0002-6068-8041

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
Scientific Human Biomarker Exposure Monitoring Core (HEMC) for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) StudyP01HL152953 · NHLBI · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2021 to 2025
$9.8M
Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCsR01HL130020 · NHLBI · STANFORD UNIVERSITY · PI Ronglih Liao, MARK MERCOLA · 2016 to 2026
$7.3M
Modeling Tyrosine Kinase Inhibitor-Induced Vascular Dysfunction Using Human iPSCsR01HL141851 · NHLBI · STANFORD UNIVERSITY · PI WONG, WING H., WU, JOSEPH C. · 2018 to 2025
$5.7M
Human iPSC Model to Elucidate Metabolic Interplay in Diabetic CardimyopathyR01HL146690 · NHLBI · STANFORD UNIVERSITY · PI LIAO, RONGLIH, MERCOLA, MARK · 2019 to 2025
$5.1M
Elucidating ECM Signaling in Cardiac Organoids with Machine Learning and Single-cell MultiomicsR01HL163680 · NHLBI · STANFORD UNIVERSITY · PI RAJADAS, JAYAKUMAR, WONG, WING H. · 2022 to 2025
$2.5M
AI/ML and iPSC-Derived Organoids for Myotonic Dystrophy Drug DiscoveryR21TR004938 · NCATS · GREENSTONE BIOSCIENCES, INC. · PI PANG, PAUL · 2024 to 2025
$303k
NCATS NIH HHS R21 TR004938NHLBI NIH HHS P01 HL141084NHLBI NIH HHS P01 HL152953NHLBI NIH HHS R01 HL130020NHLBI NIH HHS R01 HL141851NHLBI NIH HHS R01 HL146690NHLBI NIH HHS R01 HL163680
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

artificial intelligencecheminformaticsdrug discoverymachine learning

Identifiers

PMID39836754
PMCPMC11996029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.