Evidence map›Paper›PMID 39836243›Full record

ReviewMolecular biology reports2025

CDK5: Insights into its roles in diseases.

Jiahui Wang, Chong Zhang, Tingting Jiang, Yi He, Yongli Wu, Dongsheng Zhou, Jianguo Yan, Yali Zhou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiahui Wang *Institute of Pathogenic Biology, Guilin Medical University, Guilin, 541199, China.
Chong Zhang *Department of Neurology, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China.
Tingting JiangInstitute of Pathogenic Biology, Guilin Medical University, Guilin, 541199, China.
Yi HeInstitute of Pathogenic Biology, Guilin Medical University, Guilin, 541199, China.
Yongli WuInstitute of Pathogenic Biology, Guilin Medical University, Guilin, 541199, China.
Dongsheng ZhouGuangxi Medical and Health Key Cultivation Discipline Construction Project, Guilin, 541199, China.
Jianguo Yan *Guangxi Medical and Health Key Cultivation Discipline Construction Project, Guilin, 541199, China. yanjianguo@glmc.edu.cn.
Yali Zhou *Institute of Pathogenic Biology, Guilin Medical University, Guilin, 541199, China. zhouyali@glmc.edu.cn.

Funding

National Natural Science Foundation of China 82160517Natural Science Foundation of Guangxi Province 2023GXNSFAA026213
6 · The paper itself

Abstract

Cyclin-dependent kinase 5 (CDK5), a unique member of the CDK family, is a proline-directed serine/threonine protein kinase with critical roles in various physiological and pathological processes. Widely expressed in the central nervous system, CDK5 is strongly implicated in neurological diseases. Beyond its neurological roles, CDK5 is involved in metabolic disorders, psychiatric conditions, and tumor progression, contributing to processes such as proliferation, migration, immune evasion, genomic stability, and angiogenesis. This review explores the structure and biological functions of CDK5, highlighting its regulatory roles in disease development through the phosphorylation of diverse substrate proteins. Additionally, we examine the therapeutic potential of CDK5 inhibition, offering novel perspectives for disease diagnosis and treatment.

Indexed as

Cyclin-Dependent Kinase 5AnimalsHumansMetabolic DiseasesNeoplasmsNervous System DiseasesPhosphorylationCDK5 protein, humanCyclin-Dependent Kinase 5Cyclin-dependent kinase 5(CDK5)Neurodegenerative diseasesPhosphorylationProtein kinaseTumor

Identifiers

PMID39836243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.