SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Acute intermittent hypoxia in spinal cord injury gait rehabilitation: a systematic review of randomized trials.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGait impairments are one of the popular consequences of spinal cord injury (SCI). Acute intermittent hypoxia (AIH) is an innovative treatment that has recently been used to enhance motor function in patients with neurological conditions. This review aims to examine the effects of AIH on gait post-SCI, verify who most likely would benefit from the treatment, and recognize the best treatment protocol, if possible.
methodsThe search was conducted in "PubMed, MEDLINE, The Cochrane Library, Scopus, PEDro, and Web of Science" databases from inception to October 2024. This review included randomized trials involving individuals with SCI who received AIH, alone or in combination with other interventions, compared with active or passive comparators, and evaluated at least one outcome related to gait ability. The quality of the included studies was measured using the "Physiotherapy Evidence Database (PEDro)".
resultsNine studies met the eligibility criteria. In total, 158 individuals with SCI (mean age 44.45 years; 86% male) were involved in this analysis. The included studies' PEDro scores ranged from 5 to 10, with a median of 8. The main findings showed that AIH improves gait speed, walking endurance, dynamic balance, and plantar flexor strength in individuals with SCI.
conclusionAIH is a safe intervention for individuals with SCI. This review underscores the potential benefits of AIH for improving gait abilities in SCI with motor-incomplete injuries (ASIA grades C and D) at cervical, thoracic, and lumbar levels. Further studies are recommended to verify our findings.
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