Evidence map›Paper›PMID 39836215›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Association of objective subtle cognitive difficulties with amyloid-β and tau deposition compared to subjective cognitive decline.

Xiaoxie Mao, Anqi Li, Ying Wang, Yan Wang, Shuhua Ren, Kun He, Yihui Guan, Qi Huang, Qihao Guo, Zijing Li and 3 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Metabotropic glutamate receptor 5 is associated with plasma GFAP dependent on age.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaoxie Mao *School of Medicine, Xiamen University, 361102, Xiamen, Fujian, China.
Anqi Li *Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.
Ying Wang *Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, 200233, Shanghai, China.
Yan WangDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Shuhua RenDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Kun HeDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Yihui GuanDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Qi HuangDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Qihao GuoDepartment of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, 200233, Shanghai, China.
Zijing LiSchool of Medicine, Xiamen University, 361102, Xiamen, Fujian, China. zijing.li@xmu.edu.cn.
Tengfei GuoInstitute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China. tengfei.guo@pku.edu.cn.
Fang XieDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China. fangxie@fudan.edu.cn.ORCID http://orcid.org/0000-0003-2667-281X
Alzheimer’s Disease Neuroimaging Initiative

Funding

STI2030-Major Projects 2022ZD0213800the National Science Foundation of China 81801752, 82171473, 82201583, 82071962, 81971674the Shanghai Sailing Program 18YF1403200, 19YF1405300the startup fund of Huashan Hospital, Fudan University 2017QD081
6 · The paper itself

Abstract

purposeThis study evaluated the differences in amyloid-β (Aβ), tau deposition, and longitudinal tau deposition between subjective cognitive decline (SCD) and objective subtle cognitive difficulties (Obj-SCD).

methodsParticipants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (n = 234) and the Huashan cohort (n = 267) included individuals with Obj-SCD, SCD, subjective memory concern (SMC), and healthy controls (HC). General linear models (GLM) were used to compare baseline and longitudinal differences in Aβ and tau among the groups, and to examine the associations between these biomarkers.

resultsObj-SCD participants had significantly higher Aβ and tau levels compared to HC, with increased annual accumulation of Aβ and tau, especially in Braak stages III-IV. In contrast, SCD/SMC participants did not show significant differences from HC in annual Aβ and tau changes. Baseline Aβ PET correlated with annual tau PET changes in Obj-SCD (Braak III-VI) and SCD/SMC (all Braak stages), and baseline Aβ levels strongly predicted early memory decline in both Obj-SCD and SCD/SMC groups.

conclusionThis study indicates that Obj-SCD is more strongly associated with Aβ and tau biomarkers, with Aβ contributing to the progression of tau pathology and memory decline. Further research should include more longitudinal data to more robustly validate these findings and clarify the temporal relationship between Aβ and tau in preclinical Alzheimer's disease.

Indexed as

Amyloid beta-PeptidesCognitive Dysfunctiontau ProteinsAgedAged, 80 and overAlzheimer DiseaseBiomarkersFemaleHumansMaleMiddle AgedPositron-Emission TomographyAmyloid beta-PeptidesBiomarkerstau ProteinsAlzheimer’s diseaseAmyloid-β PETMemory declineObj-SCDSCD/SMCTau PET

Identifiers

PMID39836215

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.