ArticleAmerican journal of respiratory cell and molecular biology2025
Chronic Obstructive Pulmonary Disease Airway Epithelial Cell-derived Extracellular Vesicles Spread Cellular Senescence via MicroRNA-34a.
Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The Role of MicroRNAs Implicated in the Regulation of PI3K/AKT and Focal Adhesion Signaling Pathways in Chronic Obstructive Pulmonary Disease.Biochemical genetics · 2026Article
- COPD Biologics: Right Patient, Right Pathway, Right Time.Pulmonary therapy · 2026Review
- Extracellular vesicles in senescence-associated chronic lung diseases.Chinese medical journal · 2026Review
- Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026Review
- Clearance of Senescent Cells by BCLAging cell · 2026Article
- Airway basal stem cell derived extracellular vesicles promote lung repair in chronic obstructive pulmonary disease.Regenerative therapy · 2026Article
- New approaches to uncover COPD pathobiology and develop therapies.JCI insight · 2026Review
- COPD airway epithelial cells-derived extracellular vesicles contribute to endothelial dysfunction and atherosclerosis via the miR-141-3p/PDCD4 axis.Journal of nanobiotechnology · 2026Article
- Cellular plasticity and regenerative mechanisms in the lung.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Cleaning, Chasing and Calming: Promising Paradigms of Senotherapy in Aging-Related Diseases.International journal of biological sciences · 2026Review
- Article
- Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases.International journal of molecular sciences · 2025Review
- Bubble Trouble: Epithelial Extracellular Vesicles and Their microRNA Mischief in Chronic Obstructive Pulmonary Disease.American journal of respiratory cell and molecular biology · 2025Article
- Senotherapy for chronic lung disease.Pharmacological reviews · 2025Review
- Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice.Frontiers in medicine · 2025Article
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6 authors.
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Abstract
Chronic obstructive pulmonary disease (COPD) is associated with the acceleration of lung aging and the accumulation of senescent cells in lung tissue. MicroRNA-34a (miR-34a) induces senescence by suppressing the antiaging molecule sirtuin-1 (SIRT1). Senescent cells spread senescence to neighboring and distant cells, favoring COPD progression and its comorbidities. Mechanisms for spreading senescence remain undetermined but may be mediated by the transfer of microRNAs in extracellular vesicles (EVs). We analyzed the microRNA content of EVs in COPD and explored their effect on cellular senescence of healthy cells. EVs were isolated from small airway epithelial cells (SAECs) from healthy donors or patients with COPD. Recipient healthy SAECs were cultured with EVs, and the expression of miR-34a and markers of cellular senescence p21
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